Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence.

Details

Serval ID
serval:BIB_43264304AE44
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence.
Journal
Journal of Immunology
Author(s)
Harari A., Vallelian F., Meylan P.R., Pantaleo G.
ISSN
0022-1767 (Print)
ISSN-L
0022-1767
Publication state
Published
Issued date
2005
Volume
174
Number
2
Pages
1037-1045
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Memory CD4 T cell responses are functionally and phenotypically heterogeneous. In the present study, memory CD4 T cell responses were analyzed in different models of Ag-specific immune responses differing on Ag exposure and/or persistence. Ag-specific CD4 T cell responses for tetanus toxoid, HSV, EBV, CMV, and HIV-1 were compared. Three distinct patterns of T cell response were observed. A dominant single IL-2 CD4 T cell response was associated with the model in which the Ag can be cleared. Polyfunctional (single IL-2 plus IL-2/IFN-gamma plus single IFN-gamma) CD4 T cell responses were associated with Ag persistence and low Ag levels. A dominant single IFN-gamma CD4 T cell response was associated with the model of Ag persistence and high Ag levels. The results obtained supported the hypothesis that the different patterns observed were substantially influenced by different conditions of Ag exposure and persistence.
Keywords
Antigens/administration & dosage, Antigens/immunology, Antigens, Bacterial/administration & dosage, Antigens, Bacterial/immunology, Antigens, Viral/immunology, CD4-Positive T-Lymphocytes/immunology, CD4-Positive T-Lymphocytes/secretion, Chronic Disease, Cytomegalovirus/immunology, Cytomegalovirus Infections/immunology, Disease Progression, Epitopes, T-Lymphocyte/immunology, HIV Infections/drug therapy, HIV Infections/immunology, HIV-1/immunology, Herpesvirus 4, Human/immunology, Humans, Immunologic Memory/immunology, Immunophenotyping, Interleukin-2/secretion, Simplexvirus/immunology, Tetanus Toxoid/administration & dosage, Tetanus Toxoid/immunology, Virus Latency/immunology
Pubmed
Web of science
Create date
25/01/2008 15:00
Last modification date
20/08/2019 13:46
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