Mortality and high risk of major adverse events in patients with COVID-19 and history of cardiovascular disease.

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State: Public
Version: author
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_4306C0375B1D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mortality and high risk of major adverse events in patients with COVID-19 and history of cardiovascular disease.
Journal
Open heart
Author(s)
Tessitore E. (co-first), Carballo D. (co-first), Poncet A., Perrin N., Follonier C., Assouline B., Carballo S., Girardin F. (co-last), Mach F. (co-last)
ISSN
2053-3624 (Print)
ISSN-L
2053-3624
Publication state
Published
Issued date
04/2021
Peer-reviewed
Oui
Volume
8
Number
1
Pages
e001526
Language
english
Notes
Publication types: Journal Article ; Observational Study
Publication Status: ppublish
Abstract
History of cardiovascular diseases (CVDs) may influence the prognosis of patients hospitalised for COVID-19. We investigated whether patients with previous CVD have increased risk of death and major adverse cardiovascular event (MACE) when hospitalised for COVID-19.
We included 839 patients with COVID-19 hospitalised at the University Hospitals of Geneva. Demographic characteristics, medical history, laboratory values, ECG at admission and medications at admission were collected based on electronic medical records. The primary outcome was a composite of in-hospital mortality or MACE.
Median age was 67 years, 453 (54%) were males and 277 (33%) had history of CVD. In total, 152 (18%) died and 687 (82%) were discharged, including 72 (9%) who survived a MACE. Patients with previous CVD were more at risk of composite outcomes 141/277 (51%) compared with those without CVD 83/562 (15%) (OR=6.0 (95% CI 4.3 to 8.4), p<0.001). Multivariate analyses showed that history of CVD remained an independent risk factor of in-hospital death or MACE (OR=2.4; (95% CI 1.6 to 3.5)), as did age (OR for a 10-year increase=2.2 (95% CI 1.9 to 2.6)), male gender (OR=1.6 (95% CI 1.1 to 2.3)), chronic obstructive pulmonary disease (OR=2.1 (95% CI 1.0 to 4.2)) and lung infiltration associated with COVID-19 at CT scan (OR=1.9 (95% CI 1.2 to 3.0)). History of CVD (OR=2.9 (95% CI 1.7 to 5)), age (OR=2.5 (95% CI 2.0 to 3.2)), male gender (OR=1.6 (95% CI 0.98 to 2.6)) and elevated C reactive protein (CRP) levels on admission (OR for a 10 mg/L increase=1.1 (95% CI 1.1 to 1.2)) were independent risk factors for mortality.
History of CVD is associated with higher in-hospital mortality and MACE in hospitalised patients with COVID-19. Other factors associated with higher in-hospital mortality are older age, male sex and elevated CRP on admission.
Keywords
Age Factors, Aged, Aged, 80 and over, COVID-19/diagnosis, COVID-19/mortality, COVID-19/therapy, Cardiovascular Diseases/diagnosis, Cardiovascular Diseases/mortality, Cardiovascular Diseases/therapy, Cause of Death, Comorbidity, Female, Hospital Mortality, Hospitalization, Humans, Male, Middle Aged, Risk Assessment, Risk Factors, Sex Factors, Switzerland, Time Factors, COVID-19, epidemiology, global health
Pubmed
Open Access
Yes
Create date
04/05/2021 9:29
Last modification date
21/05/2021 6:35
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