Correlation between plasma concentration of cilazapril and haemodynamic and hormonal effects in healthy man.

Details

Serval ID
serval:BIB_42FE91162326
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Correlation between plasma concentration of cilazapril and haemodynamic and hormonal effects in healthy man.
Journal
British journal of clinical pharmacology
Author(s)
Burnier M., Mooser V., Nussberger J., Waeber B., Brunner H.R.
ISSN
0306-5251
Publication state
Published
Issued date
1989
Peer-reviewed
Oui
Volume
27 Suppl 2
Pages
189S-197S
Language
english
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article - Publication Status: ppublish
Abstract
1. The haemodynamic and humoral effects of cilazapril, a new angiotensin converting enzyme (ACE) inhibitor, were evaluated in normotensive healthy volunteers. 2. Single oral doses of 1.25, 2.5, 5 and 10 mg of cilazapril inhibited ACE by greater than or equal to 90% and induced the expected pattern of changes of the renin-angiotensin-aldosterone-system. 3. Cilazapril had a long duration of action, since some ACE inhibition was still present 72 h after drug intake. 4. Cilazapril administered intravenously at doses of 5 and 20 micrograms kg-1 for 24 h did not produce any significant effects. 5. During repeated administration of cilazapril for 8 days, no accumulation of cilazaprilat was observed and the clinical tolerance was excellent. 6. In normal volunteers, cilazapril administered orally acts as a potent inhibitor of converting enzyme.
Keywords
Administration, Oral, Adult, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Cilazapril, Heart Rate, Hemodynamics, Hormones, Humans, Infusions, Intravenous, Male, Pyridazines, Time Factors
Pubmed
Web of science
Create date
05/03/2008 16:39
Last modification date
20/08/2019 13:46
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