Apoptosis time course in the limbic system after myocardial infarction in the rat

Details

Serval ID
serval:BIB_42E9EDCBC59D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Apoptosis time course in the limbic system after myocardial infarction in the rat
Journal
Brain Res
Author(s)
Kaloustian S., Wann B. P., Bah T. M., Girard S. A., Apostolakis A., Ishak S., Mathieu S., Ryvlin P., Godbout R., Rousseau G.
ISSN
0006-8993 (Print)
ISSN-L
0006-8993
Publication state
Published
Issued date
2008
Volume
1216
Pages
87-91
Language
english
Notes
Kaloustian, S
Wann, B P
Bah, T M
Girard, S A
Apostolakis, A
Ishak, S
Mathieu, S
Ryvlin, P
Godbout, R
Rousseau, G
eng
Comparative Study
Research Support, Non-U.S. Gov't
Netherlands
Brain Res. 2008 Jun 24;1216:87-91. doi: 10.1016/j.brainres.2008.04.019. Epub 2008 Apr 18.
Abstract
Apoptosis is known to occur in the limbic system after myocardial infarction (MI) in the rat. Our study was designed to evaluate the time course dynamics of this phenomenon in limbic areas. Apoptosis, i.e., caspase-3 activity and the number of terminal dUTP nick-end labelling-positive cells, as well as brain-derived neurotrophic factor (BDNF) were quantitated in sham-operated controls and MI rats 1, 2 and 7 days after surgery. Both apoptosis parameters were increased throughout, although in different structures: the CA1 region of the hippocampus and the medial amygdala at day 1, the CA1 region of the hippocampus and the lateral amygdala at day 2, and the frontal cortex at day 7. At day 2, BDNF was decreased in the prefrontal cortex and medial amygdala, whereas it was elevated in the dentate gyrus of the hippocampus; at day 7, BDNF was reduced in the frontal cortex and posterior hypothalamus but was augmented in the medial amygdala. These data indicate that post-MI apoptosis in the limbic system is a dynamic process occurring mainly in the hippocampus and amygdala during the first days after MI. The fact that BDNF was increased as early as 2 days after MI suggests that neurogenesis can occur rapidly in selected limbic regions after MI.
Keywords
Amygdala/metabolism/*pathology, Animals, Apoptosis/*physiology, Brain-Derived Neurotrophic Factor/metabolism, Caspase 3/metabolism, Hippocampus/metabolism/*pathology, Limbic System/metabolism/pathology, Male, Myocardial Infarction/*pathology, Neurons/metabolism/pathology, Rats, Rats, Sprague-Dawley, Time Factors, Tissue Distribution
Pubmed
Create date
29/11/2018 13:36
Last modification date
12/01/2019 7:26
Usage data