Multispectral brain morphometry in Tourette syndrome persisting into adulthood.

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Serval ID
serval:BIB_42E9027F553F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Multispectral brain morphometry in Tourette syndrome persisting into adulthood.
Journal
Brain
Author(s)
Draganski B., Martino D., Cavanna A.E., Hutton C., Orth M., Robertson M.M., Critchley H.D., Frackowiak R.S.
ISSN
1460-2156[electronic], 0006-8950[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
133
Number
Pt 12
Pages
3661-3675
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Abstract
Tourette syndrome is a childhood-onset neuropsychiatric disorder with a high prevalence of attention deficit hyperactivity and obsessive-compulsive disorder co-morbidities. Structural changes have been found in frontal cortex and striatum in children and adolescents. A limited number of morphometric studies in Tourette syndrome persisting into adulthood suggest ongoing structural alterations affecting frontostriatal circuits. Using cortical thickness estimation and voxel-based analysis of T1- and diffusion-weighted structural magnetic resonance images, we examined 40 adults with Tourette syndrome in comparison with 40 age- and gender-matched healthy controls. Patients with Tourette syndrome showed relative grey matter volume reduction in orbitofrontal, anterior cingulate and ventrolateral prefrontal cortices bilaterally. Cortical thinning extended into the limbic mesial temporal lobe. The grey matter changes were modulated additionally by the presence of co-morbidities and symptom severity. Prefrontal cortical thickness reduction correlated negatively with tic severity, while volume increase in primary somatosensory cortex depended on the intensity of premonitory sensations. Orbitofrontal cortex volume changes were further associated with abnormal water diffusivity within grey matter. White matter analysis revealed changes in fibre coherence in patients with Tourette syndrome within anterior parts of the corpus callosum. The severity of motor tics and premonitory urges had an impact on the integrity of tracts corresponding to cortico-cortical and cortico-subcortical connections. Our results provide empirical support for a patho-aetiological model of Tourette syndrome based on developmental abnormalities, with perturbation of compensatory systems marking persistence of symptoms into adulthood. We interpret the symptom severity related grey matter volume increase in distinct functional brain areas as evidence of ongoing structural plasticity. The convergence of evidence from volume and water diffusivity imaging strengthens the validity of our findings and attests to the value of a novel multimodal combination of volume and cortical thickness estimations that provides unique and complementary information by exploiting their differential sensitivity to structural change.
Keywords
Adolescent, Adult, Aged, Attention Deficit Disorder with Hyperactivity/complications, Attention Deficit Disorder with Hyperactivity/psychology, Brain/pathology, Cerebral Cortex/pathology, Data Interpretation, Statistical, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net/pathology, Obsessive-Compulsive Disorder/complications, Obsessive-Compulsive Disorder/psychology, Tourette Syndrome/pathology, Tourette Syndrome/psychology, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
08/03/2011 10:38
Last modification date
20/08/2019 13:45
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