Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis.

Details

Serval ID
serval:BIB_42D8EECD68E5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis.
Journal
Genes and Development
Author(s)
Hu B., Lefort K., Qiu W., Nguyen B.C., Rajaram R.D., Castillo E., He F., Chen Y., Angel P., Brisken C., Dotto G.P.
ISSN
1549-5477[electronic], 0890-9369[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
24
Number
14
Pages
1519-1532
Language
english
Abstract
Epithelial-mesenchymal interactions are key to skin morphogenesis and homeostasis. We report that maintenance of the hair follicle keratinocyte cell fate is defective in mice with mesenchymal deletion of the CSL/RBP-Jkappa gene, the effector of "canonical" Notch signaling. Hair follicle reconstitution assays demonstrate that this can be attributed to an intrinsic defect of dermal papilla cells. Similar consequences on hair follicle differentiation result from deletion of Wnt5a, a specific dermal papilla signature gene that we found to be under direct Notch/CSL control in these cells. Functional rescue experiments establish Wnt5a as an essential downstream mediator of Notch-CSL signaling, impinging on expression in the keratinocyte compartment of FoxN1, a gene with a key hair follicle regulatory function. Thus, Notch/CSL signaling plays a unique function in control of hair follicle differentiation by the underlying mesenchyme, with Wnt5a signaling and FoxN1 as mediators.
Keywords
Animals, Forkhead Transcription Factors/metabolism, Gene Deletion, Hair Follicle, Immunoglobulin J Recombination Signal Sequence-Binding Protein/metabolism, Keratinocytes/metabolism, Mice, Signal Transduction, Wnt Proteins/genetics, Wnt Proteins/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
14/09/2010 15:29
Last modification date
20/08/2019 14:45
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