Obsessional slowness. Functional studies with positron emission tomography.

Details

Serval ID
serval:BIB_42B4DEB36D3C
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Obsessional slowness. Functional studies with positron emission tomography.
Journal
Brain
Author(s)
Sawle G.V., Hymas N.F., Lees A.J., Frackowiak R.S.
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Publication state
Published
Issued date
1991
Volume
114 ( Pt 5)
Pages
2191-2202
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Patients with Obsessional Slowness (OS) exhibit extreme slowness in the execution of some everyday tasks, such as washing and eating. This may be due to time-consuming rituals, checking behaviour and compulsions. On examination some have neurological signs such as a glabellar tap reflex, cogwheel rigidity or abnormal postures. The purpose of this study was to establish a functional explanation for slowness in this patient group. We have studied 6 OS patients using positron emission tomography (PET) with (15)Oxygen to measure regional cerebral oxygen metabolism and [18F]-6-Fluorodopoa (18F-dopa) to assess the integrity of the presynaptic nigrostriatal system. The findings were of focal hypermetabolism in orbital frontal, premotor and midfrontal cortex, whilst dopa uptake into caudate, putamen and medial frontal cortex was normal. The relationship of these findings to the patients' slowness is discussed.
Keywords
Adult, Brain/metabolism, Brain/radionuclide imaging, Compulsive Behavior/metabolism, Dihydroxyphenylalanine/metabolism, Fluorine Radioisotopes/diagnostic use, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder/metabolism, Oxygen/metabolism, Time Factors, Tomography, Emission-Computed
Pubmed
Web of science
Create date
25/09/2011 17:40
Last modification date
03/03/2018 16:38
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