Inhaled NO reduces leukocyte-endothelial cell interactions and myocardial dysfunction in endotoxemic rats

Details

Serval ID
serval:BIB_42B372B5EEFE
Type
Article: article from journal or magazin.
Collection
Publications
Title
Inhaled NO reduces leukocyte-endothelial cell interactions and myocardial dysfunction in endotoxemic rats
Journal
Am J Physiol Heart Circ Physiol
Author(s)
Neviere R., Guery B., Mordon S., Zerimech F., Charre S., Wattel F., Chopin C.
ISSN
0363-6135 (Print)
ISSN-L
0363-6135
Publication state
Published
Issued date
06/2000
Volume
278
Number
6
Pages
H1783-90
Language
english
Notes
Neviere, R
Guery, B
Mordon, S
Zerimech, F
Charre, S
Wattel, F
Chopin, C
eng
Am J Physiol Heart Circ Physiol. 2000 Jun;278(6):H1783-90. doi: 10.1152/ajpheart.2000.278.6.H1783.
Abstract
Inhaled nitric oxide (NO) has been shown to have some protective effect in the peripheral distal inflamed vasculature. The objective of the study was to determine whether inhaled NO would reduce endotoxin-induced leukocyte activation and myocardial contractile dysfunction. Rats were treated with either saline or endotoxin (10 mg/kg iv) and then allowed to breathe (4 h) either air or air plus NO (10 ppm). In endotoxemic rats, mesenteric venular endothelium leukocyte firm adhesion increased compared with control rats (1.15 +/- 0.32 vs. 4.08 +/- 0.96 leukocytes/100 microm; P < 0.05). Inhaled NO significantly attenuated endotoxin-induced venular endothelium leukocyte adhesion (4.08 +/- 0.96 vs. 1.86 +/- 0.76 leukocytes/100 microm; P < 0.05) and FITC-conjugated anti-intercellular adhesion molecule-1 fluorescence intensity. Endotoxin-induced myocardial dysfunction and leukocyte content increases were reduced in inhaled NO-treated rats. These observations suggest that inhaled NO reduces the degree of cardiovascular dysfunction and inflammation in endotoxemic rats.
Keywords
Administration, Inhalation, Animals, Cell Adhesion/drug effects, Cell Communication/*drug effects, Endothelium, Vascular/pathology/*physiopathology, Endotoxemia/*physiopathology, Heart/drug effects/*physiopathology, Intercellular Adhesion Molecule-1/drug effects/metabolism, Leukocytes/*physiology, Myocardial Contraction, Myocardium/enzymology/pathology, Nitric Oxide/*pharmacology, Oxidoreductases/metabolism, Peroxidase/metabolism, Rats, Rats, Sprague-Dawley, Splanchnic Circulation, Ventricular Function, Left, Venules/pathology
Pubmed
Create date
29/04/2021 10:59
Last modification date
30/04/2021 6:38
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