Contribution to the study of tetracycline bone side-effects. Absence of calcium deposition impairment in the trabecular bone of a patient treated during 3.5 years with doxycycline.

Details

Serval ID
serval:BIB_4263
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Contribution to the study of tetracycline bone side-effects. Absence of calcium deposition impairment in the trabecular bone of a patient treated during 3.5 years with doxycycline.
Journal
Zeitschrift für Rheumatologie
Author(s)
Van Linthoudt D., François R., Ott H.
ISSN
0340-1855 (Print)
ISSN-L
0340-1855
Publication state
Published
Issued date
1991
Peer-reviewed
Oui
Volume
50
Number
3
Pages
171-174
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
Tetracyclines are easily incorporated into bone; whether bone formation is impaired during this process is still a matter of debate. We therefore studied, by histomorphometry, fluorescence microscopy, and microradiography, a sample of trabecular bone from a patient with a total hip arthroplasty, treated without interruption for 3.5 years with doxycycline because of a pertrochanteric abscess. Absence of osteomalacia and a low-mineralization score of the edges of the trabeculae similar to that observed in a control group of 12 subjects suggest no interference by doxycycline with calcium deposition in bone.
Keywords
Arthritis, Infectious/drug therapy, Arthritis, Infectious/pathology, Bone Density/drug effects, Bone Density/physiology, Bone and Bones/drug effects, Bone and Bones/metabolism, Calcium/metabolism, Doxycycline/administration & dosage, Doxycycline/adverse effects, Hip Prosthesis, Humans, Ilium/drug effects, Ilium/metabolism, Male, Microradiography, Microscopy, Fluorescence, Middle Aged, Osteoarthritis, Hip/surgery, Postoperative Complications/drug therapy, Postoperative Complications/pathology, Prosthesis Failure, Reoperation, Staphylococcal Infections/drug therapy, Staphylococcal Infections/pathology
Pubmed
Web of science
Create date
19/11/2007 13:38
Last modification date
20/08/2019 14:44
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