Drug and toxin-induced bile duct disorders.

Details

Serval ID
serval:BIB_4251DAE73A49
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Drug and toxin-induced bile duct disorders.
Journal
Journal of Gastroenterology and Hepatology
Author(s)
Geubel A.P., Sempoux C.L.
ISSN
0815-9319 (Print)
ISSN-L
0815-9319
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
15
Number
11
Pages
1232-1238
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
Various drugs of toxins have been implicated in the development of a particular form of liver damage predominantly involving the bile ducts. Such liver toxicity is often associated with a clinical picture of prolonged cholestasis and may even evolve in rare instances, into the full picture of the vanishing bile duct syndrome, eventually complicated with biliary cirrhosis. Drug and toxins potentially responsible for bile duct injury are reviewed as well as the characteristics of its clinical presentation. The pathophysiologic aspects of the syndrome are also reviewed including recent data, which are strongly in favor of the role of a genetic predisposition.
Keywords
Bile Duct Diseases/chemically induced, Bile Duct Diseases/diagnosis, Cholestasis/chemically induced, Drug-Induced Liver Injury, Drug-Related Side Effects and Adverse Reactions/diagnosis, Drug-Related Side Effects and Adverse Reactions/physiopathology, Genetic Predisposition to Disease, Humans, Syndrome, Toxins, Biological
Pubmed
Web of science
Create date
20/10/2016 17:33
Last modification date
03/03/2018 16:37
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