Shared genetic architecture links energy metabolism, behavior and starvation resistance along a power-endurance axis.
Details
Serval ID
serval:BIB_42495407A383
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Shared genetic architecture links energy metabolism, behavior and starvation resistance along a power-endurance axis.
Journal
Evolution letters
ISSN
2056-3744 (Electronic)
ISSN-L
2056-3744
Publication state
Published
Issued date
02/2025
Peer-reviewed
Oui
Volume
9
Number
1
Pages
150-162
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Shared developmental, physiological, and molecular mechanisms can generate strong genetic covariances across suites of traits, constraining genetic variability, and evolvability to certain axes in multivariate trait space ("variational modules" or "syndromes"). Such trait suites will not only respond jointly to selection; they will also covary across populations that diverged from one another by genetic drift. We report evidence for such a genetically correlated trait suite that links traits related to energy metabolism along a "power-endurance" axis in Drosophila melanogaster. The "power" pole of the axis is characterized by high potential for energy generation and expenditure-high expression of glycolysis and TCA cycle genes, high abundance of mitochondria, and high spontaneous locomotor activity. The opposite "endurance" pole is characterized by high triglyceride (fat) reserves, locomotor endurance, and starvation resistance (and low values of traits associated with the "power" pole). This trait suite also aligns with the first principal component of metabolome; the "power" direction is characterized by low levels of trehalose (blood sugar) and high levels of some amino acids and their derivatives, including creatine, a compound known to facilitate energy production in muscles. Our evidence comes from six replicate "Selected" populations adapted to a nutrient-poor larval diet regime during 250 generations of experimental evolution and six "Control" populations evolved in parallel on a standard diet regime. We found that, within each of these experimental evolutionary regimes, the above traits strongly covaried along this "power-endurance" axis across replicate populations which diversified by drift, indicating a shared genetic architecture. The two evolutionary regimes also drove divergence along this axis, with Selected populations on average displaced towards the "power" direction compared to Controls. Aspects of this "power-endurance" axis resemble the "pace of life" syndrome and the "thrifty phenotype"; it may have evolved as part of a coordinated organismal response to nutritional conditions.
Keywords
dietary adaptation, experimental evolution, metabolome, physiology, trait syndromes, variational modules
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / 31003A_162732
Swiss National Science Foundation / 310030_184791
University of Lausanne
Create date
19/12/2024 15:44
Last modification date
17/02/2025 16:35