Sevelamer hydrochloride: A novel treatment of hyperphosphatemia associated with tumor lysis syndrome in children

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_41E43DE5FBF7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sevelamer hydrochloride: A novel treatment of hyperphosphatemia associated with tumor lysis syndrome in children
Journal
Pediatric Blood and Cancer
Author(s)
Abdullah  Shaker, Diezi  Manuel, Sung  Lillian, Dupuis  L. Lee, Geary  Denis, Abla  Oussama
ISSN
0008-5472
Publication state
Published
Issued date
2008
Volume
51
Number
1
Pages
59-61
Language
english
Abstract
Background. Sevelamer is a phosphate-binder used effectively for the treatment of hyperphosphatemia in patients treated with dialysis. Objectives. To describe the safety of sevelamer in children with hyperphosphatemia secondary to tumor lysis syndrome and the serum phosphate concentrations observed following its administration. Procedure. A retrospective chart review of all children with leukemia/lymphoma diagnosed between November 2002 and April 2004 who received sevelamer during their initial admission was conducted. We monitored the effects of sevelamer on serum phosphate concentration, calcium/phosphate product and renal function at hours 24, 48, and 72 from sevelamer initiation. Results. Thirteen patients received sevelamer during the Study period. Their median age was 13 years (range 2.7-17.9) and eight were boys. Nine children had acute lymphoblastic leukemia, one had acute myeloid leukemia and 3 had non-Hodgkin's lymphoma. The most frequently used dose of sevelamer was 400 mg orally twice daily. The median duration of sevelamer therapy was 2 days (range 1 -7). Two children were excluded from the efficacy analysis due to concurrent use of dialysis. Mean serum phosphate levels decreased after sevelamer administration, in eleven patients, from a baseline 2.2 mmol/L +/- 0.4 (95% Cl, 1.7-3.1) to 1.1 mmol/L +/- 0.2 at hour 72 (95%Cl, 0.6-1.5). The only toxicity attributed to sevelamer was mild vomiting in three patients. Conclusions. Sevelamer appears to be effective and tolerable for the treatment of hyperphosphatemia associated with tumor lysis syndrome.
Keywords
children, hyperphosphatemia, sevelamer, tumor lysis, Free Phosphate Binder, Calcium, Renagel(R)
Web of science
Create date
13/10/2009 15:10
Last modification date
20/08/2019 14:43
Usage data