Repeated maximal-intensity hypoxic exercise superimposed to hypoxic residence boosts skeletal muscle transcriptional responses in elite team-sport athletes.

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Serval ID
serval:BIB_41C08F9D203B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Repeated maximal-intensity hypoxic exercise superimposed to hypoxic residence boosts skeletal muscle transcriptional responses in elite team-sport athletes.
Journal
Acta physiologica
Author(s)
Brocherie F., Millet G.P., D'Hulst G., Van Thienen R., Deldicque L., Girard O.
ISSN
1748-1716 (Electronic)
ISSN-L
1748-1708
Publication state
Published
Issued date
01/2018
Peer-reviewed
Oui
Volume
222
Number
1
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To determine whether repeated maximal-intensity hypoxic exercise induces larger beneficial adaptations on the hypoxia-inducible factor-1α pathway and its target genes than similar normoxic exercise, when combined with chronic hypoxic exposure.
Lowland elite male team-sport athletes underwent 14 days of passive normobaric hypoxic exposure [≥14 h·day <sup>-1</sup> at inspired oxygen fraction (F <sub>i</sub> O <sub>2</sub> ) 14.5-14.2%] with the addition of six maximal-intensity exercise sessions either in normobaric hypoxia (F <sub>i</sub> O <sub>2</sub> ~14.2%; LHTLH; n = 9) or in normoxia (F <sub>i</sub> O <sub>2</sub> 20.9%; LHTL; n = 11). A group living in normoxia with no additional maximal-intensity exercise (LLTL; n = 10) served as control. Before (Pre), immediately after (Post-1) and 3 weeks after (Post-2) the intervention, muscle biopsies were obtained from the vastus lateralis.
Hypoxia-inducible factor-1α subunit, vascular endothelial growth factor, myoglobin, peroxisome proliferator-activated receptor-gamma coactivator 1-α and mitochondrial transcription factor A mRNA levels increased at Post-1 (all P ≤ 0.05) in LHTLH, but not in LHTL or LLTL, and returned near baseline levels at Post-2. The protein expression of citrate synthase increased in LHTLH (P < 0.001 and P < 0.01 at Post-1 and Post-2, respectively) and LLTL (P < 0.01 and P < 0.05 at Post-1 and Post-2, respectively), whereas it decreased in LHTL at Post-1 and Post-2 (both P < 0.001).
Combined with residence in normobaric hypoxia, repeated maximal-intensity hypoxic exercise induces short-term post-intervention beneficial changes in muscle transcriptional factors that are of larger magnitude (or not observed) than with similar normoxic exercise. The decay of molecular adaptations was relatively fast, with most of benefits already absent 3 weeks post-intervention.
Keywords
Adaptation, Physiological/physiology, Adult, Athletes, Double-Blind Method, High-Intensity Interval Training, Hockey, Humans, Hypoxia/physiopathology, Male, Muscle, Skeletal/metabolism, Muscle, Skeletal/physiopathology, Young Adult, gene, hypoxia, maximal-intensity, oxygen sensor system, physical exercise, protein
Pubmed
Web of science
Create date
30/01/2017 20:24
Last modification date
16/02/2021 7:26
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