Antigen Receptor Signaling to NF-kappa B via CARMA1, BCL10, and MALT1

Details

Serval ID
serval:BIB_41B78E27731C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Antigen Receptor Signaling to NF-kappa B via CARMA1, BCL10, and MALT1
Journal
Cold Spring Harbor Perspectives in Biology
Author(s)
Thome M., Charton J. E., Pelzer C., Hailfinger S.
ISSN
1943-0264
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
2
Number
9
Pages
a003004
Language
english
Abstract
The signaling pathway controlling antigen receptor-induced regulation of the transcription factor NF-kappa B plays a key role in lymphocyte activation and development and the generation of lymphomas. Work of the past decade has led to dramatic progress in the identification and characterization of new players in the pathway. Moreover, novel enzymatic activities relevant for this pathway have been discovered, which represent interesting drug targets for immuno-suppression or lymphoma treatment. Here, we summarize these findings and give an outlook on interesting open issues that need to be addressed in the future.
Keywords
T-CELL-ACTIVATION, CASPASE RECRUITMENT DOMAIN, UBIQUITIN LIGASE, KINASE-BETA, INDUCED PHOSPHORYLATION, LYMPHOCYTE DEVELOPMENT, CONTAINING PROTEIN, IKK ACTIVATION, COMPLEX, PARACASPASE
Web of science
Open Access
Yes
Create date
26/11/2010 10:32
Last modification date
20/08/2019 13:42
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