Fatal and nonfatal AIDS and non-AIDS events in HIV-1-positive individuals with high CD4 cell counts according to viral load strata.
Details
Serval ID
serval:BIB_4183E8E65CD8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fatal and nonfatal AIDS and non-AIDS events in HIV-1-positive individuals with high CD4 cell counts according to viral load strata.
Journal
Aids
Contributor(s)
EuroSIDA in EuroCoord, Elias C., Hospital JM., Mejia R., Aires B., Vetter N., Zangerle R., Karpov I., Vassilenko A., Mitsura VM., Suetnov O., Clumeck N., De Wit S., Delforge M., Colebunders R., Vandekerckhove L., Hadziosmanovic V., Kostov K., Begovac J., Machala L., Jilich D., Sedlacek D., Nielsen J., Kronborg G., Benfield Y., Larsen M., Gerstoft J., Katzenstein T., Hansen AB., Skinhøj P., Pedersen C., Ostergaard L., Zilmer K., Smidt J., Ristola M., Viard JP., Girard PM., Livrozet JM., Vanhems P., Pradier C., Dabis F., Neau D., Rockstroh J., Schmidt R., van Lunzen J., Degen O., Stellbrink HJ., Staszewski S., Bogner J., Kosmidis J., Gargalianos P., Xylomenos G., Perdios J., Panos G., Filandras A., Karabatsaki E., Sambatakou H., Banhegyi D., Mulcahy F., Turner D., Burke M., Pollack S., Hassoun G., Maayan S., Vella S., Esposito R., Mazeu I., Mussini C., Arici C., Pristera R., Mazzotta F., Gabbuti A., Vullo V., Lichtner M., Chirianni A., Montesarchio E., Gargiulo M., Antonucci G., Testa A., Narciso P., Vlassi C., Zaccarelli M., Lazzarin A., Castagna A., Gianotti N., Galli M., Ridolfo A., Sacco L., d'Arminio Monforte A., Rozentale B., Zeltina I., Chaplinskas S., Hemmer R., Staub T., Reiss P., Ormaasen V., Maeland A., Bruun J., Knysz B., Gasiorowski J., Knysz B., Gasiorowski J., Horban A., Grzeszczuk A., Flisiak R., Boron-Kaczmarska A., Pynka M., Parczewski M., Mularska E., Trocha H., Jablonowska E., Malolepsza E., Wojcik K., Antunes F., Doroana M., Caldeir L., Mansinho K., Maltez F., Duiculescu D., Zakharova N., Buzunova S., Jevtovic D., Staneková D., Tomazic J., González-Lahoz J., Soriano V., Labarga P., Medrano J., Moreno S., Rodriguez JM., Clotet B., Jou A., Paredes R., Tural C., Puig J., Bravo I., Miró JM., Domingo P., Gutierrez M., Mateo G., Sambeat MA., Karlsson A., Flamholc L., Ledergerber B., Weber R., Cavassini M., Hirschel B., Boffi E., Furrer H., Battegay M., Elzi L., Kravchenko E., Chentsova N., Frolov V., Kutsyna G., Servitskiy S., Barton S., Johnson AM., Mercey D., Phillips A., Johnson MA., Murphy M., Weber J., Scullard G., Fisher M., Leen C., Gazzard B., Horban A., Ledergerber B., Lundgren J., d'Arminio-Monforte A., Pedersen C., Phillips A., Reiss P., Ristola M., Rockstroh J., De Wit S., Lundgren J., Kirk O., Cozzi-Lepri A., Grint D., Ellefson M., Podlekareva D., Kjær J., Peters L., Tverland J., Fischer AH., Nielsen J.
ISSN
1473-5571 (Electronic)
ISSN-L
0269-9370
Publication state
Published
Issued date
2011
Volume
25
Number
18
Pages
2259-2268
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
BACKGROUND: This study compared the incidence of fatal and nonfatal AIDS and non-AIDS events in HIV-positive individuals with a CD4 cell count more than 350 cells/μl among viral load strata: low (<500 copies/ml), intermediate (500-9999.9 copies/ml) and high (≥ 10000 copies/ml).
METHODS: Individuals contributed person-years at risk if their most recent CD4 cell count was more than 350 cells/μl. Follow-up was censored if their CD4 cell count dropped below 350 cells/μl. Poisson regression analysis investigated the relationship between viraemia and the incidence of AIDS and non-AIDS events.
RESULTS: Three hundred and fifty-four AIDS events occurred during 51 732 person-years of follow-up (PYFU), crude incidence rate of AIDS across the three strata was 0.53, 0.90 and 2.12 per 100 PYFU, respectively. After adjustment, a higher rate of AIDS was observed in individuals with moderate [incidence rate ratio (IRR) 1.44, 1.02-2.05, P = 0.03] and high viraemia had a higher rate (IRR 3.91, 2.89-5.89, P < 0.0001) compared with low viraemia. Five hundred and seventy-two non-AIDS events occurred during 43 784 PYFU, the crude incidence rates were 1.28, 1.52, and 1.38 per 100 PYFU, respectively. After adjustment, particularly for age, region of Europe and starting combination antiretroviral therapy, there was a 61% (IRR 1.61, 1.21-2.14, P = 0.001) and 66% (IRR 1.66, 1.17-2.32, P = 0.004) higher rate of non-AIDS in individuals with intermediate and high viraemia compared with low viraemia.
CONCLUSION: In individuals with a CD4 cell count more than 350 cells/μl, an increased incidence of AIDS and a slightly increased incidence of non-AIDS was found in those with uncontrolled viral replication. The association with AIDS was clear and consistent. However, the association with non-AIDS was only apparent after adjustment and no differences were observed between intermediate and high viraemia.
METHODS: Individuals contributed person-years at risk if their most recent CD4 cell count was more than 350 cells/μl. Follow-up was censored if their CD4 cell count dropped below 350 cells/μl. Poisson regression analysis investigated the relationship between viraemia and the incidence of AIDS and non-AIDS events.
RESULTS: Three hundred and fifty-four AIDS events occurred during 51 732 person-years of follow-up (PYFU), crude incidence rate of AIDS across the three strata was 0.53, 0.90 and 2.12 per 100 PYFU, respectively. After adjustment, a higher rate of AIDS was observed in individuals with moderate [incidence rate ratio (IRR) 1.44, 1.02-2.05, P = 0.03] and high viraemia had a higher rate (IRR 3.91, 2.89-5.89, P < 0.0001) compared with low viraemia. Five hundred and seventy-two non-AIDS events occurred during 43 784 PYFU, the crude incidence rates were 1.28, 1.52, and 1.38 per 100 PYFU, respectively. After adjustment, particularly for age, region of Europe and starting combination antiretroviral therapy, there was a 61% (IRR 1.61, 1.21-2.14, P = 0.001) and 66% (IRR 1.66, 1.17-2.32, P = 0.004) higher rate of non-AIDS in individuals with intermediate and high viraemia compared with low viraemia.
CONCLUSION: In individuals with a CD4 cell count more than 350 cells/μl, an increased incidence of AIDS and a slightly increased incidence of non-AIDS was found in those with uncontrolled viral replication. The association with AIDS was clear and consistent. However, the association with non-AIDS was only apparent after adjustment and no differences were observed between intermediate and high viraemia.
Keywords
AIDS-Related Opportunistic Infections/epidemiology, AIDS-Related Opportunistic Infections/immunology, Acquired Immunodeficiency Syndrome/immunology, Acquired Immunodeficiency Syndrome/mortality, Adult, Argentina/epidemiology, CD4 Lymphocyte Count, Disease Progression, Europe/epidemiology, Female, Follow-Up Studies, HIV Infections/epidemiology, HIV Infections/immunology, HIV-1, Humans, Incidence, Israel/epidemiology, Male, Prospective Studies, Risk Factors, Viral Load, Viremia
Pubmed
Web of science
Create date
08/12/2011 12:56
Last modification date
20/08/2019 14:42
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