Systemic corticosteroids for subcutaneous panniculitis-like T-cell lymphoma.

Details

Serval ID
serval:BIB_41732CDCD148
Type
Article: article from journal or magazin.
Collection
Publications
Title
Systemic corticosteroids for subcutaneous panniculitis-like T-cell lymphoma.
Journal
The British journal of dermatology
Author(s)
Guenova E., Schanz S., Hoetzenecker W., DeSimone J.A., Mehra T., Voykov B., Urosevic-Maiwald M., Berneburg M., Dummer R., French L.E., Kerl K., Kamarashev J., Fierlbeck G., Cozzio A.
ISSN
1365-2133 (Electronic)
ISSN-L
0007-0963
Publication state
Published
Issued date
10/2014
Peer-reviewed
Oui
Volume
171
Number
4
Pages
891-894
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Primary cutaneous γ/δ T-cell lymphoma (PCGD-TCL) is aggressive and has a poor prognosis. In contrast, subcutaneous panniculitis-like T-cell lymphoma (SPTCL) of the α/β T-cell receptor phenotype is known to follow an indolent course and have a more favourable prognosis. In the past, PCGD-TCL and SPTCL were often considered to be a manifestation of the same disease, and aggressive systemic polychemotherapy has commonly been the first-line therapy for both. Given the understanding that SPTCL is a separate and less aggressive entity, clinical data exclusively evaluating the efficacy of conservative treatment in SPTCL are needed.
To assess the overall clinical response to systemic corticosteroids in the treatment of SPTCL.
This was a retrospective cross-sectional study based on a patient data repository from two tertiary care university hospitals in Zürich (Switzerland) and Tübingen (Germany). The repository spanned 13 years.
In four of the five patients (80%) with SPTCL, treatment with systemic corticosteroids induced a complete remission.
Systemic corticosteroids may be an excellent first-line single-agent therapy for SPTCL.
Keywords
Adult, Aged, Antineoplastic Agents, Hormonal/therapeutic use, Cross-Sectional Studies, Female, Humans, Lymphoma, T-Cell/drug therapy, Male, Middle Aged, Panniculitis/drug therapy, Prednisolone/therapeutic use, Retrospective Studies, Skin Neoplasms/drug therapy, Treatment Outcome
Pubmed
Web of science
Create date
27/08/2020 14:59
Last modification date
02/09/2020 6:26
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