Chronic treatment of hypertensive patients with converting enzyme inhibitors.

Details

Serval ID
serval:BIB_417056A26A5D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Chronic treatment of hypertensive patients with converting enzyme inhibitors.
Journal
Journal of cardiovascular pharmacology
Author(s)
Nussberger J., Biollaz J., Waeber B., Brunner H.R.
ISSN
0160-2446
Publication state
Published
Issued date
1986
Peer-reviewed
Oui
Volume
8 Suppl 1
Pages
S20-5
Language
english
Notes
Publication types: Clinical Trial ; Journal Article - Publication Status: ppublish
Abstract
It is widely accepted that pharmacologic reduction of the blood pressure of hypertensive patients reduces the risk of at least some of the major cardiovascular complications (1-5). All major studies were carried out before orally active converting enzyme inhibitors had become available. In other words, very effective antihypertensive drugs have been around for quite some time and have already proven their efficacy. Therefore, the considerable enthusiasm that has developed during the very recent years for the new converting enzyme inhibitors should be evaluated in the light of previously available antihypertensive drugs, the more so, as drugs cheaper than converting enzyme inhibiting agents are presently available. Thus, the increased expense when using this new class of antihypertensive compounds should be justified by a therapeutic gain. When evaluating a class of antihypertensive drugs such as converting enzyme inhibitors, there are basically three main considerations: What is their efficacy in long-term use? This includes the effect on blood pressure, on heart, on hemodynamics, and on blood flow distribution. What are the metabolic effects? What is the effect on sodium and potassium excretion? How are the serum lipids affected by its use? Are there any untoward effects related either to the chemical structure of the compound per se or rather to the approach? In particular, are there any central effects of the drug which can cause discomfort to the patient? The following discussion has the principal aim to review these aspects with chronic use of oral converting enzyme inhibiting agents without, however, even attempting to provide an exhaustive review of the subject.
Keywords
Angiotensin I, Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Animals, Blood Pressure, Cerebrovascular Circulation, Clinical Trials as Topic, Coronary Circulation, Enalapril, Heart Rate, Humans, Hypertension, Lipids, Oligopeptides, Peptidyl-Dipeptidase A, Potassium, Rats, Rats, Inbred SHR, Renin, Sodium, Teprotide
Pubmed
Web of science
Create date
05/03/2008 17:41
Last modification date
20/08/2019 14:41
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