Exploring the brain epitranscriptome: perspectives from the NSAS summit.

Details

Serval ID
serval:BIB_416B229518A8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Exploring the brain epitranscriptome: perspectives from the NSAS summit.
Journal
Frontiers in neuroscience
Author(s)
Lee S.M., Koo B., Carré C., Fischer A., He C., Kumar A., Liu K., Meyer K.D., Ming G.L., Peng J., Roignant J.Y., Storkebaum E., Sun S., De Pietri Tonelli D., Wang Y., Weng Y.L., Pulvirenti L., Shi Y., Yoon K.J., Song H.
ISSN
1662-4548 (Print)
ISSN-L
1662-453X
Publication state
Published
Issued date
10/2023
Peer-reviewed
Oui
Volume
17
Pages
1291446
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neurodegeneration, and brain tumorigenesis, leading to the emergence of a new field termed neuroepitranscriptomics. Deficiency in machineries modulating RNA modifications has been implicated in a range of brain disorders from microcephaly, intellectual disability, seizures, and psychiatric disorders to brain cancers such as glioblastoma. The inaugural NSAS Challenge Workshop on Brain Epitranscriptomics hosted in Crans-Montana, Switzerland in 2023 assembled a group of experts from the field, to discuss the current state of the field and provide novel translational perspectives. A summary of the discussions at the workshop is presented here to simulate broader engagement from the general neuroscience field.
Keywords
RNA modifications, epitranscriptome, glioblastoma, neurodevelopment, neuroepitranscriptomics, neurogenesis
Pubmed
Web of science
Open Access
Yes
Create date
10/11/2023 11:17
Last modification date
16/11/2023 7:11
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