Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank.

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_4169BEAD7145
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank.
Journal
Molecular psychiatry
Author(s)
Coleman JRI, Peyrot W.J., Purves K.L., Davis KAS, Rayner C., Choi S.W., Hübel C., Gaspar H.A., Kan C., Van der Auwera S., Adams M.J., Lyall D.M., Choi K.W., Dunn E.C., Vassos E., Danese A., Maughan B., Grabe H.J., Lewis C.M., O'Reilly P.F., McIntosh A.M., Smith D.J., Wray N.R., Hotopf M., Eley T.C., Breen G.
Working group(s)
on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Contributor(s)
Wray N.R., Ripke S., Mattheisen M., Trzaskowski M., Byrne E.M., Abdellaoui A., Adams M.J., Agerbo E., Air T.M., Andlauer TFM, Bacanu S.A., Bækvad-Hansen M., Beekman ATF, Bigdeli T.B., Binder E.B., Bryois J., Buttenschøn H.N., Bybjerg-Grauholm J., Cai N., Castelao E., Christensen J.H., Clarke T.K., Coleman JRI, Colodro-Conde L., Couvy-Duchesne B., Craddock N., Crawford G.E., Davies G., Deary I.J., Degenhardt F., Derks E.M., Direk N., Dolan C.V., Dunn E.C., Eley T.C., Escott-Price V., Kiadeh FFH, Finucane H.K., Foo J.C., Forstner A.J., Frank J., Gaspar H.A., Gill M., Goes F.S., Gordon S.D., Grove J., Hall L.S., Hansen C.S., Hansen T.F., Herms S., Hickie I.B., Hoffmann P., Homuth G., Horn C., Hottenga J.J., Hougaard D.M., Howard D.M., Ising M., Jansen R., Jones I., Jones L.A., Jorgenson E., Knowles J.A., Kohane I.S., Kraft J., Kretzschmar W.W., Kutalik Z., Li Y., Lind P.A., MacIntyre D.J., MacKinnon D.F., Maier R.M., Maier W., Marchini J., Mbarek H., McGrath P., McGuffin P., Medland S.E., Mehta D., Middeldorp C.M., Mihailov E., Milaneschi Y., Milani L., Mondimore F.M., Montgomery G.W., Mostafavi S., Mullins N., Nauck M., Ng B., Nivard M.G., Nyholt D.R., O'Reilly P.F., Oskarsson H., Owen M.J., Painter J.N., Pedersen C.B., Pedersen M.G., Peterson R.E., Pettersson E., Peyrot W.J., Pistis G., Posthuma D., Quiroz J.A., Qvist P., Rice J.P., Riley B.P., Rivera M., Mirza S.S., Schoevers R., Schulte E.C., Shen L., Shi J., Shyn S.I., Sigurdsson E., Sinnamon GCB, Smit J.H., Smith D.J., Stefansson H., Steinberg S., Streit F., Strohmaier J., Tansey K.E., Teismann H., Teumer A., Thompson W., Thomson P.A., Thorgeirsson T.E., Traylor M., Treutlein J., Trubetskoy V., Uitterlinden A.G., Umbricht D., Van der Auwera S., van Hemert A.M., Viktorin A., Visscher P.M., Wang Y., Webb B.T., Weinsheimer S.M., Wellmann J., Willemsen G., Witt S.H., Wu Y., Xi H.S., Yang J., Zhang F., Arolt V., Baune B.T., Berger K., Boomsma D.I., Cichon S., Dannlowski U., de Geus EJC, DePaulo J.R., Domenici E., Domschke K., Esko T., Grabe H.J., Hamilton S.P., Hayward C., Heath A.C., Kendler K.S., Kloiber S., Lewis G., Li Q.S., Lucae S., Madden PAF, Magnusson P.K., Martin N.G., McIntosh A.M., Metspalu A., Mors O., Mortensen P.B., Müller-Myhsok B., Nordentoft M., Nöthen M.M., O'Donovan M.C., Paciga S.A., Pedersen N.L., Penninx BWJH, Perlis R.H., Porteous D.J., Potash J.B., Preisig M., Rietschel M., Schaefer C., Schulze T.G., Smoller J.W., Stefansson K., Tiemeier H., Uher R., Völzke H., Weissman M.M., Werge T., Lewis C.M., Levinson D.F., Breen G., Børglum A.D., Sullivan P.F.
ISSN
1476-5578 (Electronic)
ISSN-L
1359-4184
Publication state
Published
Issued date
07/2020
Peer-reviewed
Oui
Volume
25
Number
7
Pages
1430-1446
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Abstract
Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD stratified by reported trauma exposure (final sample size range: 24,094-92,957). The SNP-based heritability of MDD with reported trauma exposure (24%) was greater than MDD without reported trauma exposure (12%). Simulations showed that this is not confounded by the strong, positive genetic correlation observed between MDD and reported trauma exposure. We also observed that the genetic correlation between MDD and waist circumference was only significant in individuals reporting trauma exposure (r <sub>g</sub> = 0.24, p = 1.8 × 10 <sup>-7</sup> versus r <sub>g</sub> = -0.05, p = 0.39 in individuals not reporting trauma exposure, difference p = 2.3 × 10 <sup>-4</sup> ). Our results suggest that the genetic contribution to MDD is greater when reported trauma is present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.
URN
urn:nbn:ch:serval-BIB_4169BEAD71456
OAI-PMH
oai:serval.unil.ch:BIB_4169BEAD7145
DOI
10.1038/s41380-019-0546-6
Pubmed
31969693
Web of science
000509565100001
Create date
18/02/2020 10:45
Last modification date
30/04/2021 6:09
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