Emerging roles of Keap1/Nrf2 signaling in the thyroid gland and perspectives for bench-to-bedside translation.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_415D504588B6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Emerging roles of Keap1/Nrf2 signaling in the thyroid gland and perspectives for bench-to-bedside translation.
Journal
Free radical biology & medicine
Author(s)
Chartoumpekis D.V., Ziros P.G., Habeos I.G., Sykiotis G.P.
ISSN
1873-4596 (Electronic)
ISSN-L
0891-5849
Publication state
Published
Issued date
18/08/2022
Peer-reviewed
Oui
Volume
190
Pages
276-283
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
The signaling pathway centered on the transcription factor nuclear erythroid factor 2-like 2 (Nrf2) has emerged during the last 15 years as a target for the prevention and treatment of diseases broadly related with oxidative stress such as cancer, neurodegenerative and metabolic diseases. The roles of Nrf2 are expanding beyond general cytoprotection, and they encompass its crosstalk with other pathways as well as tissue-specific functions. The thyroid gland relies on reactive oxygen species for its main physiological function, the synthesis and secretion of thyroid hormones. A few years ago, Nrf2 was characterized as a central regulator of the antioxidant response in the thyroid, as well as of the transcription and processing of thyroglobulin, the major thyroidal protein that serves as the substrate for thyroid hormone synthesis. Herein, we summarize the current knowledge about the roles of Nrf2 in thyroid physiology, pathophysiology and disease. We focus specifically on the most recent publications in the field, and we discuss the implications for the preclinical and clinical use of Nrf2 modulators.
Keywords
Goiter, Hyperthyroidism, Hypothyroidism, Nfe2l2, Oxidative stress, Reactive oxygen species, Thyroglobulin
Pubmed
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Projects / 31003A_182105
Swiss National Science Foundation / Programmes / IZCOZ0_177070
Create date
30/08/2022 9:54
Last modification date
02/09/2022 7:09
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