Antiviral therapy of primary cytomegalovirus infection with vascular thrombosis in immunocompetent adults.

Details

Serval ID
serval:BIB_4155C8E0D5D5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Antiviral therapy of primary cytomegalovirus infection with vascular thrombosis in immunocompetent adults.
Journal
Medecine et maladies infectieuses
Author(s)
Deconinck L., Flateau C., Pichenot M., Morell-Dubois S., Maillard H., Hatron P.Y., Guery B., Faure K.
ISSN
1769-6690 (Electronic)
ISSN-L
0399-077X
Publication state
Published
Issued date
03/2016
Peer-reviewed
Oui
Volume
46
Number
2
Pages
87-92
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Vascular thromboembolism (VTE) complicating cytomegalovirus (CMV) primary infection is increasingly reported in immunocompetent adults. No guideline is, however, currently available for the management of these infections and particularly for the antiviral therapy indication.
We performed a literature review of VTE complicating CMV primary infection in immunocompetent adults using PubMed.
Sixty-nine case patients of VTE complicating CMV primary infection were reported. The main sites of venous thrombosis were the splanchnic veins (30 patients) or those of the lower limbs (18 patients). One-third of patients presented with pulmonary embolism (25 patients). Forty-nine patients (76%) had at least one VTE risk factor, inherited or acquired thrombophilia for 37 patients (58%), and another risk factor for 27 patients (42%). Only 11 patients received an antiviral therapy. A positive outcome was observed in all patients.
We suggest that antiviral therapy should be considered for patients presenting with severe VTE, VTE with a negative outcome despite anticoagulation, severe organ involvement, or for patients managed in the intensive care unit.

Pubmed
Create date
23/01/2017 17:36
Last modification date
20/08/2019 14:41
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