The glucocorticoid-induced leucine zipper (gilz/tsc22d3-2) gene locus plays a crucial role in male fertility.

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Version: Author's accepted manuscript
Serval ID
serval:BIB_413D486D499A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The glucocorticoid-induced leucine zipper (gilz/tsc22d3-2) gene locus plays a crucial role in male fertility.
Journal
Molecular Endocrinology
Author(s)
Suarez P.E., Rodriguez E.G., Soundararajan R., Mérillat A.M., Stehle J.C., Rotman S., Roger T., Voirol M.J., Wang J., Gross O., Pétrilli V., Nadra K., Wilson A., Beermann F., Pralong F.P., Maillard M., Pearce D., Chrast R., Rossier B.C., Hummler E.
ISSN
1944-9917 (Electronic)
ISSN-L
0888-8809
Publication state
Published
Issued date
2012
Volume
26
Number
6
Pages
1000-1013
Language
english
Abstract
The glucocorticoid-induced leucine zipper (Tsc22d3-2) is a widely expressed dexamethasone-induced transcript that has been proposed to be important in immunity, adipogenesis, and renal sodium handling based on in vitro studies. To address its function in vivo, we have used Cre/loxP technology to generate mice deficient for Tsc22d3-2. Male knockout mice were viable but surprisingly did not show any major deficiencies in immunological processes or inflammatory responses. Tsc22d3-2 knockout mice adapted to a sodium-deprived diet and to water deprivation conditions but developed a subtle deficiency in renal sodium and water handling. Moreover, the affected animals developed a mild metabolic phenotype evident by a reduction in weight from 6 months of age, mild hyperinsulinemia, and resistance to a high-fat diet. Tsc22d3-2-deficient males were infertile and exhibited severe testis dysplasia from postnatal d 10 onward with increases in apoptotic cells within seminiferous tubules, an increased number of Leydig cells, and significantly elevated FSH and testosterone levels. Thus, our analysis of the Tsc22d3-2-deficient mice demonstrated a previously uncharacterized function of glucocorticoid-induced leucine zipper protein in testis development.
Pubmed
Web of science
Create date
08/06/2012 11:21
Last modification date
20/10/2020 11:12
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