Mitral regurgitation.

Details

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State: Serval
Version: Final published version
Serval ID
serval:BIB_412926AF6387
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Mitral regurgitation.
Journal
Swiss medical weekly
Author(s)
Pedrazzini G.B., Faletra F., Vassalli G., Demertzis S., Moccetti T.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
23/01/2010
Peer-reviewed
Oui
Volume
140
Number
3-4
Pages
36-43
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Mitral regurgitation (MR) involves systolic retrograde flow from the left ventricle into the left atrium. While trivial MR is frequent in healthy subjects, moderate to severe MR constitutes the second most prevalent valve disease after aortic valve stenosis. Major causes of severe MR in Western countries include degenerative valve disease (myxomatous disease, flail leaflet, annular calcification) and ischaemic heart disease, while rheumatic disease remains a major cause of MR in developing countries. Chronic MR typically progresses insidiously over many years. Once established, however, severe MR portends a poor prognosis. The severity of MR can be assessed by various techniques, Doppler echocardiography being the most widely used. Mitral valve surgery is the only treatment of proven efficacy. It alleviates clinical symptoms and prevents ventricular dilatation and heart failure (or, at least, it attenuates further progression of these abnormalities). Valve repair significantly improves clinical outcomes compared with valve replacement, reducing mortality by approximately 70%. Reverse LV remodelling after valve repair occurs in half of patients with functional MR. Percutaneous, catheter-based to mitral valve repair is a novel approach currently under clinical scrutiny, with encouraging preliminary results. This modality may provide a valuable alternative to mitral valve surgery, especially in critically ill patients.

Keywords
Aged, Female, Humans, Male, Mitral Valve/abnormalities, Mitral Valve Insufficiency
Pubmed
Web of science
Create date
18/02/2010 12:35
Last modification date
25/05/2018 14:53
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