Central fat excess in polycystic ovary syndrome: relation to low-grade inflammation and insulin resistance
Details
Serval ID
serval:BIB_41270EA4574F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Central fat excess in polycystic ovary syndrome: relation to low-grade inflammation and insulin resistance
Journal
Journal of Clinical Endocrinology and Metabolism
ISSN
0021-972X
Publication state
Published
Issued date
11/2005
Peer-reviewed
Oui
Volume
90
Number
11
Pages
6014-21
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Research Support, Non-U.S. Gov't --- Old month value: Nov
Abstract
BACKGROUND: It is controversial whether the polycystic ovary syndrome (PCOS) per se increases low-grade chronic inflammation and whether this relates to central fat excess. In addition, the association between circulating sex hormones and body fat distribution in premenopausal women is debated. METHODS: Blood was drawn from 20 patients with PCOS and compared with 15 controls, matched for body mass index and age. Regional fat distribution was assessed using dual x-ray absorptiometry. RESULTS: Compared with controls, patients with PCOS had a higher trunk to extremity fat ratio (T/E fat), were more insulin resistant (higher homeostasis model assessment of insulin resistance and lower SHBG concentrations), and had higher levels of highly sensitive C-reactive protein, TNF-alpha, procalcitonin, and white blood cell count (all P < or = 0.04), even after adjusting for total body fat. However, additional adjusting for T/E fat eliminated or attenuated the effect of PCOS status on estimates of insulin resistance, on inflammatory mediators, and on white blood cell count but not on circulating sex hormones. Independently of each other, total body fat as well as T/E fat correlated with estimates of insulin resistance and most inflammatory mediators (P < or = 0.04). However, the correlations between T/E fat and circulating sex hormones (P < or = 0.02) were greatly reduced after adjustment for the presence of PCOS. CONCLUSION: The increase in low-grade chronic inflammation and in insulin resistance in women with PCOS is primarily associated with increased central fat excess rather than PCOS status per se. Procalcitonin represents a novel marker of the inflammatory activity of body fat and of PCOS.
Keywords
Adipose Tissue/*metabolism
Adult
Body Fat Distribution
C-Reactive Protein/analysis
Chronic Disease
Estradiol/blood
Female
Humans
Inflammation/*etiology
*Insulin Resistance
Interleukin-6/blood
Obesity/complications
Polycystic Ovary Syndrome/complications/*metabolism
Tumor Necrosis Factor-alpha/analysis
Pubmed
Web of science
Open Access
Yes
Create date
15/02/2008 18:19
Last modification date
20/08/2019 14:40