Bumetanide for autism: more eye contact, less amygdala activation.

Details

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_412575543314
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Bumetanide for autism: more eye contact, less amygdala activation.
Journal
Scientific reports
Author(s)
Hadjikhani N., Åsberg Johnels J., Lassalle A., Zürcher N.R., Hippolyte L., Gillberg C., Lemonnier E., Ben-Ari Y.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
26/02/2018
Peer-reviewed
Oui
Volume
8
Number
1
Pages
3602
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
We recently showed that constraining eye contact leads to exaggerated increase of amygdala activation in autism. Here, in a proof of concept pilot study, we demonstrate that administration of bumetanide (a NKCC1 chloride importer antagonist that restores GABAergic inhibition) normalizes the level of amygdala activation during constrained eye contact with dynamic emotional face stimuli in autism. In addition, eye-tracking data reveal that bumetanide administration increases the time spent in spontaneous eye gaze during in a free-viewing mode of the same face stimuli. In keeping with clinical trials, our data support the Excitatory/Inhibitory dysfunction hypothesis in autism, and indicate that bumetanide may improve specific aspects of social processing in autism. Future double-blind placebo controlled studies with larger cohorts of participants will help clarify the mechanisms of bumetanide action in autism.
Keywords
Adolescent, Adult, Amygdala/diagnostic imaging, Amygdala/drug effects, Amygdala/physiology, Autistic Disorder/diagnostic imaging, Autistic Disorder/physiopathology, Bumetanide/pharmacology, Bumetanide/therapeutic use, Double-Blind Method, Emotions/drug effects, Emotions/physiology, Female, Fixation, Ocular/drug effects, Fixation, Ocular/physiology, Humans, Magnetic Resonance Spectroscopy, Male, Pilot Projects, Sodium Potassium Chloride Symporter Inhibitors/pharmacology, Sodium Potassium Chloride Symporter Inhibitors/therapeutic use, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
03/03/2018 15:07
Last modification date
28/09/2019 6:08
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