La maladie d'alzheimer: perspectives therapeutiques [Alzheimer's disease: therapeutic perspectives]

Details

Serval ID
serval:BIB_40E65125B62F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
La maladie d'alzheimer: perspectives therapeutiques [Alzheimer's disease: therapeutic perspectives]
Journal
Bulletin de l'Academie nationale de medecine
Author(s)
Dubois B., De Souza L., Allali G., Kalafat M., Sarazin M.
ISSN
0001-4079 (Print)
ISSN-L
0001-4079
Publication state
Published
Issued date
02/2008
Peer-reviewed
Oui
Volume
192
Number
2
Pages
333-42; discussion 343-4
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review
Publication Status: ppublish
Abstract
Current treatments for Alzheimer's disease aim to compensate for biochemical deficits in the brain. They are purely symptomatic and restore the central cholinergic deficit. Acetylcholinesterase inhibitors have modest but significant efficacy on cognitive disorders, activities of daily living, and the global clinical impression. Glutaminergic receptor antagonists are used for more advanced forms. Future treatments may be curative, acting specifically on the amyloid cascade. Secretase inhibitors and immunotherapy are in the pipeline. Trials will begin within a few months and will open up new perspectives.
Keywords
Alzheimer Disease/drug therapy, Alzheimer Disease/therapy, Alzheimer Vaccines/therapeutic use, Amyloid Precursor Protein Secretases/antagonists & inhibitors, Amyloid beta-Peptides/therapeutic use, Amyloid beta-Protein Precursor/metabolism, Animals, Cholinesterase Inhibitors/therapeutic use, Clinical Trials, Phase II as Topic, Drug Delivery Systems, Drug Evaluation, Preclinical, Excitatory Amino Acid Antagonists/therapeutic use, Humans, Immunotherapy, Nootropic Agents/therapeutic use, Peptide Fragments/therapeutic use, Receptors, Glutamate/drug effects, tau Proteins/antagonists & inhibitors
Pubmed
Web of science
Create date
11/08/2023 13:49
Last modification date
03/10/2023 5:58
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