The bioavailability of bromazepam, omeprazole and paracetamol given by nasogastric feeding tube.

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Serval ID
serval:BIB_40E54B8E7B5F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The bioavailability of bromazepam, omeprazole and paracetamol given by nasogastric feeding tube.
Journal
European Journal of Clinical Pharmacology
Author(s)
Podilsky G., Berger-Gryllaki M., Testa B., Buclin T., Roulet M., Pannatier A.
ISSN
1432-1041[electronic]
Publication state
Published
Issued date
2009
Volume
65
Number
5
Pages
435-442
Language
english
Abstract
AIMS: To characterize and compare the pharmacokinetic profiles of bromazepam, omeprazole and paracetamol when administered by the oral and nasogastric routes to the same healthy cohort of volunteers. METHODS: In a prospective, monocentric, randomized crossover study, eight healthy volunteers received the three drugs by the oral (OR) and nasogastric routes (NT). Sequential plasma samples were analyzed by high-performance liquid chromatography-UV, pharmacokinetic parameters (Cmax, AUC(0-infinity), t(1/2), k(e), tmax) were compared statistically, and Cmax, AUC(0-infinity) and t(max) were analyzed for bioequivalence. RESULTS: A statistically significant difference was seen in the AUC(0-infinity) of bromazepam, with nasogastric administration decreasing availability by about 25%: AUC(OR) = 2501 ng mL(-1) h; AUC(NT) = 1855 ng mL(-1) h (p < 0.05); ratio (geometric mean) = 0.74 [90% confidence interval (CI) 0.64-0.87]. However, this does not appear to be clinically relevant given the usual dosage range and the drug's half-life (approx. 30 h). A large interindividual variability in omeprazole parameters prevented any statistical conclusion from being drawn in terms of both modes of administration despite their similar average profile: AUC(OR) = 579 ng mL(-1) h; AUC(NT) = 587 ng mL(-1) h (p > 0.05); ratio (geometric mean) = 1.01 (90% CI 0.64-1.61). An extended study with a larger number of subjects may possibly provide clearer answers. The narrow 90% confidence limits of paracetamol indicate bioequivalence: AUC(OR) = 37 microg mL(-1) h; AUC(NT) = 41 microg mL(-1) h(p > 0.05); ratio (geometric mean) = 1.12 (90% CI 0.98-1.28). CONCLUSION: The results of this study show that the nasogastric route of administration does not appear to cause marked, clinically unsuitable alterations in the bioavailability of the tested drugs.
Keywords
Acetaminophen/administration & dosage, Acetaminophen/blood, Administration, Oral, Analgesics, Non-Narcotic/administration & dosage, Analgesics, Non-Narcotic/blood, Anti-Anxiety Agents/administration & dosage, Anti-Anxiety Agents/blood, Anti-Ulcer Agents/administration & dosage, Anti-Ulcer Agents/blood, Area Under Curve, Biological Availability, Bromazepam/administration & dosage, Bromazepam/blood, Cohort Studies, Cross-Over Studies, Female, Half-Life, Humans, Intubation, Gastrointestinal, Male, Metabolic Clearance Rate, Omeprazole/administration & dosage, Omeprazole/blood, Prospective Studies, Reproducibility of Results, Therapeutic Equivalency
Pubmed
Web of science
Open Access
Yes
Create date
02/09/2009 10:52
Last modification date
23/11/2020 11:06
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