Pattern formation in the Drosophila eye disc.

Details

Serval ID
serval:BIB_40D05C9D20EB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Pattern formation in the Drosophila eye disc.
Journal
The International journal of developmental biology
Author(s)
Roignant J.Y., Treisman J.E.
ISSN
1696-3547 (Electronic)
ISSN-L
0214-6282
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
53
Number
5-6
Pages
795-804
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Review
Publication Status: ppublish
Abstract
Differentiation of the Drosophila compound eye from the eye imaginal disc is a progressive process: columns of cells successively differentiate in a posterior to anterior sequence, clusters of cells form at regularly spaced intervals within each column, and individual photoreceptors differentiate in a defined order within each cluster. The progression of differentiation across the eye disc is driven by a positive autoregulatory loop of expression of the secreted molecule Hedgehog, which is temporally delayed by the intercalation of a second signal, Spitz. Hedgehog refines the spatial position at which each column initiates its differentiation by inducing secondary signals that act over different ranges to control the expression of positive and negative regulators. The position of clusters within each column is controlled by secreted inhibitory signals from clusters in the preceding column, and a single founder neuron, R8, is singled out within each cluster by Notch-mediated lateral inhibition. R8 then sequentially recruits surrounding cells to differentiate by producing a short-range signal, Spitz, which induces a secondary short-range signal, Delta. Intrinsic transcription factors act in combination with these two signals to produce cell-type diversity within the ommatidium. The Hedgehog and Spitz signals are transported along the photoreceptor axons and reused within the brain as long-range and local cues to trigger the differentiation and assembly of target neurons.
Keywords
Animals, Body Patterning, Cell Differentiation, Developmental Biology/methods, Drosophila/embryology, Drosophila/physiology, Drosophila Proteins/metabolism, Epidermal Growth Factor/metabolism, Gene Expression Regulation, Developmental, Hedgehog Proteins/metabolism, Intracellular Signaling Peptides and Proteins, Membrane Proteins/metabolism, Models, Biological, Neurons/physiology, Photoreceptor Cells, Invertebrate/cytology, Photoreceptor Cells, Invertebrate/pathology, Transcription Factors/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
28/10/2019 12:59
Last modification date
29/10/2019 6:26
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