Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors.

Details

Serval ID
serval:BIB_40CC1D9BD3C7
Type
Article: article from journal or magazin.
Collection
Publications
Title
Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors.
Journal
Journal of Virology
Author(s)
van den Broek M.F., Müller U., Huang S., Aguet M., Zinkernagel R.M.
ISSN
0022-538X (Print)
ISSN-L
0022-538X
Publication state
Published
Issued date
1995
Volume
69
Number
8
Pages
4792-4796
Language
english
Abstract
Alpha/beta interferon (IFN) and gamma IFN exert widely overlapping biological effects. Still, mice with individually inactivated alpha/beta or gamma receptors exhibit variably severely reduced resistance to infection and altered immune responses. To investigate to what extent the two IFN systems are functionally redundant, we generated mice with a combined receptor defect (AG129 mice). Like mice with individual mutations, AG129 mice had no apparent anomalies, confirming that in the mouse the IFN system is not essential for normal development. These mice showed an additive phenotype with respect to antiviral defense and exhibited an increased susceptibility to lymphocytic choriomeningitis virus (LCMV) and notably vaccinia virus infection. Because of unlimited replication and subsequent rapid exhaustion of cytotoxic T lymphocyte (CTL) precursors, these mice were unable to mount a CTL response to LCMV. CD8(+)-mediated immunopathology was absent in LCMV-infected mice, and virus persisted. Vaccinia virus replicated much faster in AG129 mice, and a 10(4)-fold lower dose of vaccinia virus was sufficient to prime these mice. With the normal priming dose of 10(6) PFU, cytopathic effects and overwhelming infection possibly causing partial exhaustion of CTL interfered with the anti-vaccinia virus response. Even though global antiviral immunoglobulin G (IgG) titers were within normal ranges, the IgG subclass distribution was heavily biased toward IgG1.
Keywords
Animals, Female, Immunity, Cellular, Lymphocytic Choriomeningitis/immunology, Lymphocytic choriomeningitis virus/physiology, Male, Membrane Proteins, Mice, Phenotype, Receptor, Interferon alpha-beta, Receptors, Interferon/deficiency, Spodoptera, T-Lymphocytes, Cytotoxic/immunology, Vaccinia/immunology, Vaccinia virus/physiology
Pubmed
Web of science
Create date
28/01/2008 11:36
Last modification date
20/08/2019 13:39
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