Cone photoreceptor definition on adaptive optics retinal imaging.

Details

Serval ID
serval:BIB_40C9FA8361EF
Type
Article: article from journal or magazin.
Collection
Publications
Title
Cone photoreceptor definition on adaptive optics retinal imaging.
Journal
The British journal of ophthalmology
Author(s)
Muthiah M.N., Gias C., Chen F.K., Zhong J., McClelland Z., Sallo F.B., Peto T., Coffey P.J., da Cruz L.
ISSN
1468-2079 (Electronic)
ISSN-L
0007-1161
Publication state
Published
Issued date
08/2014
Peer-reviewed
Oui
Volume
98
Number
8
Pages
1073-1079
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To quantitatively analyse cone photoreceptor matrices on images captured on an adaptive optics (AO) camera and assess their correlation to well-established parameters in the retinal histology literature.
High resolution retinal images were acquired from 10 healthy subjects, aged 20-35 years old, using an AO camera (rtx1, Imagine Eyes, France). Left eye images were captured at 5° of retinal eccentricity, temporal to the fovea for consistency. In three subjects, images were also acquired at 0, 2, 3, 5 and 7° retinal eccentricities. Cone photoreceptor density was calculated following manual and automated counting. Inter-photoreceptor distance was also calculated. Voronoi domain and power spectrum analyses were performed for all images.
At 5° eccentricity, the cone density (cones/mm(2) mean±SD) was 15.3±1.4×10(3) (automated) and 13.9±1.0×10(3) (manual) and the mean inter-photoreceptor distance was 8.6±0.4 μm. Cone density decreased and inter-photoreceptor distance increased with increasing retinal eccentricity from 2 to 7°. A regular hexagonal cone photoreceptor mosaic pattern was seen at 2, 3 and 5° of retinal eccentricity.
Imaging data acquired from the AO camera match cone density, intercone distance and show the known features of cone photoreceptor distribution in the pericentral retina as reported by histology, namely, decreasing density values from 2 to 7° of eccentricity and the hexagonal packing arrangement. This confirms that AO flood imaging provides reliable estimates of pericentral cone photoreceptor distribution in normal subjects.
Keywords
Adult, Cell Count, Feasibility Studies, Female, Humans, Male, Ophthalmoscopy/methods, Optics and Photonics/methods, Photography/methods, Retina/anatomy & histology, Retinal Cone Photoreceptor Cells/cytology, Visual Fields/physiology, Young Adult, Adaptive Optics, Cone Photoreceptor, Retinal Imaging
Pubmed
Web of science
Open Access
Yes
Create date
26/09/2024 20:18
Last modification date
27/09/2024 16:46
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