Presenilin-1 expression in Pick's disease.

Details

Serval ID
serval:BIB_40B84A1707EB
Type
Article: article from journal or magazin.
Collection
Publications
Title
Presenilin-1 expression in Pick's disease.
Journal
Acta Neuropathologica
Author(s)
Giannakopoulos P., Kövari E., Buée L., Shioi J., Hof P.R., Robakis N.K., Bouras C.
ISSN
0001-6322 (Print)
ISSN-L
0001-6322
Publication state
Published
Issued date
1999
Volume
98
Number
5
Pages
488-492
Language
english
Abstract
Recent studies have reported that neuronal populations expressing low levels of presenilin-1 (PS-1) display increased vulnerability in late-onset sporadic Alzheimer's disease (AD). To examine whether this phenomenon also occurs in other neurodegenerative diseases, we performed a quantitative immunocytochemical study of PS-1 distribution in the cerebral cortex of Pick's disease (PiD) cases and non-demented individuals. In PiD cases, the percentage of PS-1-containing, Pick body (PB)-free neurons was significantly elevated only in cortical areas showing neuronal loss. In these areas, PS-1 levels, measured by immunoblotting, were often higher in PiD compared to non-demented cases. Moreover, PS-1 immunoreactivity was significantly reduced in PB-containing neurons. These data suggest that as previously shown in AD, low cellular expression of PS-1 may be associated with increased neuronal loss and cellular degeneration.
Keywords
Aged, Female, Hippocampus/pathology, Humans, Immunohistochemistry, Male, Membrane Proteins/analysis, Neurons/pathology, Pick Disease of the Brain/pathology, Presenilin-1
Pubmed
Web of science
Create date
14/10/2011 19:59
Last modification date
20/08/2019 13:39
Usage data