Effects of social support on the clinical course of Crohn's disease.

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State: Public
Version: author
Serval ID
serval:BIB_40AD3A24FBA9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of social support on the clinical course of Crohn's disease.
Journal
Inflammatory Bowel Diseases
Author(s)
Cámara Rafael J.A., Lukas Paul S., Begré Stefan, Pittet Valérie, von Känel Roland
Working group(s)
Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS) Group
ISSN
1536-4844[electronic]
ISSN-L
1078-0998
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
17
Number
6
Pages
1277-1286
Language
english
Abstract
BACKGROUND: Social support has been found to be protective from adverse health effects of psychological stress. We hypothesized that higher social support would predict a more favorable course of Crohn's disease (CD) directly (main effect hypothesis) and via moderating other prognostic factors (buffer hypothesis). METHODS: Within a multicenter cohort study we observed 597 adults with CD for 18 months. We assessed social support using the ENRICHD Social Support Inventory. Flares, nonresponse to therapy, complications, and extraintestinal manifestations were recorded as a combined endpoint indicating disease deterioration. We controlled for several demographic, psychosocial, and clinical variables of potential prognostic importance. We used multivariate binary logistic regression to estimate the overall effect of social support on the odds of disease deterioration and to explore main and moderator effects of social support by probing interactions with other predictors. RESULTS: The odds of disease deterioration decreased by 1.5 times (95% confidence interval [CI]: 1.2-1.9) for an increase of one standard deviation (SD) of social support. In case of low body mass index (BMI) (i.e., 1 SD below the mean or <19 kg/m(2)), the odds decreased by 1.8 times for an increase of 1 SD of social support. In case of low social support, the odds increased by 2.1 times for a decrease of 1 SD of BMI. Low BMI was not predictive under high social support. CONCLUSIONS: The findings suggest that elevated social support may favorably affect the clinical course of CD, particularly in patients with low BMI. (Inflamm Bowel Dis 2010;).
Keywords
Crohn Disease/psychology , Social Support
Pubmed
Web of science
Create date
02/03/2011 8:27
Last modification date
20/08/2019 13:39
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