Orbital amyloidosis and radiotherapy: A case report and review of literature.

Details

Serval ID
serval:BIB_4090FD39342B
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Orbital amyloidosis and radiotherapy: A case report and review of literature.
Journal
Cancer radiotherapie
Author(s)
Bennassi A., Kinj R., Chaabouni S., Khanfir K.
ISSN
1769-6658 (Electronic)
ISSN-L
1278-3218
Publication state
Published
Issued date
11/2022
Peer-reviewed
Oui
Volume
26
Number
8
Pages
1070-1074
Language
english
Notes
Publication types: Review ; Case Reports
Publication Status: ppublish
Abstract
An 80 year-old woman was referred for a one-eyed palpebral edema. She had ptosis and oblique diplopia resistant to corticotherapy. An orbit magnetic resonance imaging showed a mass infiltrating the optic nerve, with an enhancement of the whole orbital musculature. Biopsies of the lacrimal gland were positive for immunoglobulin light chain amyloidosis. Debulking surgery is the main treatment modality for symptomatic patients with localized orbital amyloidosis. Diffuse orbital involvement may make excision difficult. We managed to treat her through radiation therapy to allow a surgical procedure, delivering 20Gy in 10 fractions. The main aim of radiation therapy was to eradicate the B cells that produced the amyloid light chain deposition. After radiation therapy, the orbital inflammatory caused by the lymphoid infiltration diminished and corticotherapy could be stopped. The surgery could be performed with excellent clinical results. At 2-year follow-up, neither tumor regrowth nor late complications were detected.
Keywords
Humans, Female, Aged, 80 and over, Amyloidosis/pathology, Amyloidosis/radiotherapy, Amyloidosis/surgery, Magnetic Resonance Imaging, Biopsy, Amylose orbitaire, Chirurgie., Orbital amyloidosis, Radiation therapy, Radiothérapie, Surgery.
Pubmed
Create date
15/08/2022 13:33
Last modification date
24/11/2022 6:46
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