Lithium infusion to study sodium handling in unanesthetized hypertensive rats

Details

Serval ID
serval:BIB_408F8470874C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lithium infusion to study sodium handling in unanesthetized hypertensive rats
Journal
Hypertension
Author(s)
Biollaz  J., Waeber  B., Diezi  J., Burnier  M., Brunner  H. R.
ISSN
0194-911X
Publication state
Published
Issued date
02/1986
Peer-reviewed
Oui
Volume
8
Number
2
Pages
117-21
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Abstract
To investigate renal tubular handling of sodium in various types of experimental hypertension, sodium, lithium, and inulin clearances were measured simultaneously in unanesthetized rats. Fractional excretion of lithium was used as an index of proximal sodium reabsorption. Eight groups of animals, all of the Wistar-Kyoto strain, were studied. Three were hypertensive: spontaneously hypertensive rats (SHR), rats with two-kidney, one clip renal hypertension, and uninephrectomized rats with deoxycorticosterone-salt hypertension. The five normotensive control groups included animals given normal, low, or high dietary sodium loads and rats with reduced renal mass. Fractional excretion of lithium was not influenced by moderate changes of glomerular filtration rate, but was sharply enhanced by sodium loading. Increased blood pressure was associated with enhanced urinary sodium excretion in uninephrectomized deoxycorticosterone-salt hypertensive and two-kidney, one clip hypertensive rats, as a result of decreased distal tubular reabsorption ("pressure natriuresis"). In contrast, SHR showed reduced sodium excretion and decreased fractional excretion of lithium, which suggests that increased sodium reabsorption in the proximal tubule may contribute significantly to the maintenance of hypertension.
Keywords
Animals Blood Pressure Glomerular Filtration Rate Hypertension/*metabolism Hypertension, Renal/metabolism Inulin/metabolism Kidney Tubules/metabolism Lithium/*diagnostic use/metabolism Male Rats Rats, Inbred SHR Rats, Inbred Strains Renin/blood Sodium/*metabolism
Pubmed
Web of science
Create date
21/01/2008 11:54
Last modification date
20/08/2019 13:39
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