Forearm vascular resistance increases during static exercise in heart transplant recipients

Details

Serval ID
serval:BIB_407DC0FE9B1E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Forearm vascular resistance increases during static exercise in heart transplant recipients
Journal
Journal of Applied Physiology
Author(s)
Morgan  B. J., DeBoer  L. W., Pease  M. O., Scherrer  U., Vissing  S. F., Hanson  P.
ISSN
8750-7587 (Print)
Publication state
Published
Issued date
12/1991
Volume
71
Number
6
Pages
2224-30
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
In heart transplant recipients but not in normal humans, total peripheral vascular resistance increases during static exercise. To determine whether this augmented vasoconstriction limits the vasodilation normally seen in the nonexercising forearm, we measured arterial pressure, heart rate, and forearm blood flow during 30% maximal static handgrip in 9 heart transplant recipients and 10 control subjects. Handgrip evoked comparable increases in mean arterial pressure in the transplant recipients and control subjects (+19 +/- 2 vs. +20 +/- 2 mmHg). Heart rates increased by 14 +/- 3 beats/min in the control subjects but did not change in the transplant recipients. Directionally opposite patterns of forearm vascular resistance were observed in the two groups. In the control subjects, forearm resistance fell during handgrip (-8.8 +/- 1.9 units, P less than 0.05). In contrast, in the transplant recipients, forearm resistance rose during this intervention (+9.0 +/- 2.9 units, P less than 0.05). Thus the vasodilation that normally occurs in the nonexercising forearm during static handgrip is reversed in heart transplant recipients. Vasoconstriction in the forearm contributes to the increase in total peripheral resistance that occurs during static exercise in these individuals.
Keywords
Adult Exercise/*physiology Female Forearm Heart Transplantation/*physiology Humans Male Middle Aged Stress, Psychological/physiopathology Vascular Resistance/*physiology Vasoconstriction/physiology Vasodilation/physiology
Pubmed
Web of science
Create date
25/01/2008 14:04
Last modification date
20/08/2019 13:39
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