Cell wall precursors are required to organize the chlamydial division septum.

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Serval ID
serval:BIB_407BCA55AA57
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cell wall precursors are required to organize the chlamydial division septum.
Journal
Nature Communications
Author(s)
Jacquier N., Frandi A., Pillonel T., Viollier P.H., Viollier P., Greub G.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
5
Pages
3578
Language
english
Notes
Publication in OA
Abstract
Members of the Chlamydiales order are major bacterial pathogens that divide at mid-cell, without a sequence homologue of the FtsZ cytokinetic tubulin and without a classical peptidoglycan cell wall. Moreover, the spatiotemporal mechanisms directing constriction in Chlamydia are not known. Here we show that the MreB actin homologue and its conserved regulator RodZ localize to the division furrow in Waddlia chondrophila, a member of the Chlamydiales order implicated in human miscarriage. RodZ is recruited to the septal site earlier than MreB and in a manner that depends on biosynthesis of the peptidoglycan precursor lipid II by the MurA enzyme. By contrast, crosslinking of lipid II peptides by the Pbp3 transpeptidase disperses RodZ from the septum. Altogether, these findings provide a cytological framework for understanding chlamydial cytokinesis driven by septal cell wall synthesis.
Keywords
Alkyl and Aryl Transferases/metabolism, Bacterial Proteins/physiology, Cell Division/physiology, Cell Wall/physiology, Chlamydiales/physiology, Cytokinesis/physiology, Cytoskeletal Proteins/physiology, Uridine Diphosphate N-Acetylmuramic Acid/analogs & derivatives, Uridine Diphosphate N-Acetylmuramic Acid/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
20/10/2015 17:31
Last modification date
20/08/2019 13:39
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