Unavailability of CD147 leads to selective erythrocyte trapping in the spleen.

Details

Serval ID
serval:BIB_407241FCCB6D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Unavailability of CD147 leads to selective erythrocyte trapping in the spleen.
Journal
Blood
Author(s)
Coste I., Gauchat J.F., Wilson A., Izui S., Jeannin P., Delneste Y., MacDonald H.R., Bonnefoy J.Y., Renno T.
ISSN
0006-4971
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
97
Number
12
Pages
3984-3988
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Adhesive interactions with stromal cells and the extracellular matrix are essential for the differentiation and migration of hematopoietic progenitors. In the erythrocytic lineage, a number of adhesion molecules are expressed in the developing erythrocytes and are thought to play a role in the homing and maturation of erythrocytic progenitors. However, many of these molecules are lost during the final developmental stages leading to mature erythrocytes. One of the adhesion molecules that remains expressed in mature, circulating erythrocytes is CD147. This study shows that blockade of this molecule on the cell surface by treatment with F(ab')(2) fragments of anti-CD147 monoclonal antibody disrupts the circulation of erythrocytes, leading to their selective trapping in the spleen. Consequently, mice develop an anemia, and de novo, erythropoietin-mediated erythropoiesis in the spleen. In contrast, these changes were not seen in mice similarly treated with another antierythrocyte monoclonal antibody with a different specificity. These results suggest that the CD147 expressed on erythrocytes likely plays a critical role in the recirculation of mature erythrocytes from the spleen into the general circulation. (Blood. 2001;97:3984-3988)
Keywords
Animals, Antibodies, Monoclonal/pharmacology, Antigens, CD, Antigens, CD147, Antigens, Neoplasm, Antigens, Surface, Avian Proteins, Blood Proteins, Cell Movement/drug effects, Erythrocytes/cytology, Erythrocytes/drug effects, Erythropoiesis/drug effects, Hematocrit, Membrane Glycoproteins/immunology, Membrane Glycoproteins/pharmacology, Mice, Mice, Inbred Strains, Organ Size/drug effects, Phlebotomy, Spleen/cytology, Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
11/02/2010 11:08
Last modification date
20/08/2019 14:38
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