Female hormonal factors and the development of anti-citrullinated protein antibodies in women at risk of rheumatoid arthritis.

Details

Serval ID
serval:BIB_405C17539F5B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Female hormonal factors and the development of anti-citrullinated protein antibodies in women at risk of rheumatoid arthritis.
Journal
Rheumatology
Author(s)
Alpizar-Rodriguez D., Mueller R.B., Möller B., Dudler J., Ciurea A., Zufferey P., Kyburz D., Walker U.A., von Mühlenen I., Roux-Lombard P., Mahler M., Lamacchia C., Courvoisier D.S., Gabay C., Finckh A.
ISSN
1462-0332 (Electronic)
ISSN-L
1462-0324
Publication state
Published
Issued date
01/09/2017
Peer-reviewed
Oui
Volume
56
Number
9
Pages
1579-1585
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To analyse the association between female hormonal factors and the development of systemic autoimmunity associated with RA in women at increased risk for RA, namely first-degree relatives of patients with RA (RA-FDRs).
In an ongoing cohort study of RA-FDRs, we analysed all women with available ACPA status. The primary outcome was ACPA positivity. The predictors of interest were female hormonal factors, such as oral contraceptives, breastfeeding, post-menopausal status, early post-menopausal period and total number of ovulatory years.
A total of 768 female RA-FDRs were analysed, of which 42 (5%) had developed ACPA positivity. ACPA-positive women were older (52 vs 44 years, P = 0.001). Hormonal factors significantly and independently associated with the presence of ACPA were the post-menopausal (P < 0.001) and the early post-menopausal periods (P = 0.040).
In women at increased risk of RA, characteristic systemic autoimmunity was associated with menopause, suggesting that the acute decline in ovarian function might contribute to the development of autoimmunity associated with RA and potentially to the increased risk of RA in women.

Keywords
anticitrullinated protein antibodies, autoantibodies, biomarkers, epidemiology, reproductive, rheumatoid arthritis, risk factors, women
Pubmed
Web of science
Open Access
Yes
Create date
22/09/2017 14:23
Last modification date
20/08/2019 14:38
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