tRNA biology in the omics era: Stress signalling dynamics and cancer progression.

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Ressource 1Download: Orioli-2017-BioEssays.pdf (649.65 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_402CF1A89D55
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
tRNA biology in the omics era: Stress signalling dynamics and cancer progression.
Journal
BioEssays
Author(s)
Orioli A.
ISSN
1521-1878 (Electronic)
ISSN-L
0265-9247
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
39
Number
3
Pages
1
Language
english
Abstract
Recent years have seen a burst in the number of studies investigating tRNA biology. With the transition from a gene-centred to a genome-centred perspective, tRNAs and other RNA polymerase III transcripts surfaced as active regulators of normal cell physiology and disease. Novel strategies removing some of the hurdles that prevent quantitative tRNA profiling revealed that the differential exploitation of the tRNA pool critically affects the ability of the cell to balance protein homeostasis during normal and stress conditions. Furthermore, growing evidence indicates that the adaptation of tRNA synthesis to cellular dynamics can influence translation and mRNA stability to drive carcinogenesis and other pathological disorders. This review explores the contribution given by genomics, transcriptomics and epitranscriptomics to the discovery of emerging tRNA functions, and gives insights into some of the technical challenges that still limit our understanding of the RNA polymerase III transcriptional machinery.

Keywords
epitranscriptomics, genomics, high-throughput, RNA polymerase III, transcriptomics, tRNA
Pubmed
Web of science
Open Access
Yes
Create date
17/04/2017 16:55
Last modification date
20/08/2019 13:37
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