Connexin40 regulates renin production and blood pressure.

Details

Serval ID
serval:BIB_4029A2D5D3FA
Type
Article: article from journal or magazin.
Collection
Publications
Title
Connexin40 regulates renin production and blood pressure.
Journal
Kidney international
Author(s)
Krattinger N., Capponi A., Mazzolai L., Aubert J.F., Caille D., Nicod P., Waeber G., Meda P., Haefliger J.A.
ISSN
0085-2538
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
72
Number
7
Pages
814-22
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Renin secretion is regulated by coordinated signaling between the various cells of the juxtaglomerular apparatus. The renin-secreting cells (RSC), which play a major role in the control of blood pressure, are coupled to each other and to endothelial cells by Connexin40 (Cx40)-containing channels. In this study, we show that Cx40 knockout (Cx40-/-) mice, but not their heterozygous littermates, are hypertensive due to the increase in the number of RSC, renin biosynthesis, and plasma renin. Treatment with the angiotensin II receptor AT1 antagonist candesartan or the angiotensin II-converting enzyme inhibitor ramipril reduced the blood pressure of the Cx40-/- mice to the same levels seen in wild-type (WT) mice. The elevated blood pressure of the knockout mice was not affected by clipping one renal artery (2K1C, renin-dependent model of hypertension) or after a high salt diet. Under these conditions, however, Cx40-/- mice showed an altered production and release of renin. The renin mRNA ratio between the clipped and the non-clipped kidney was lower in the knockout than in the WT 2K1C mice. This indicates that the response to a change in blood pressure was altered. The RSC of the Cx40-/- mice did not have a compensatory increase in the levels of either Cx43 or Cx37. Our data show that renin secretion is dependent on Cx40 and suggest the Cx40-/- mice may be a genetic model of renin-dependent hypertension.
Keywords
Animals, Blood Pressure, Connexins, Hypertension, Kidney, Mice, Mice, Inbred C57BL, Mice, Knockout, Renin, Renin-Angiotensin System
Pubmed
Web of science
Open Access
Yes
Create date
17/11/2008 9:57
Last modification date
20/08/2019 14:37
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