Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disorders.
Details
Serval ID
serval:BIB_40026FF2936E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disorders.
Journal
Frontiers in cellular neuroscience
ISSN
1662-5102 (Print)
ISSN-L
1662-5102
Publication state
Published
Issued date
2024
Peer-reviewed
Oui
Volume
18
Pages
1354259
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Abstract
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by elusive underlying mechanisms. Recent attention has focused on the involvement of astrocytes and microglia in ASD pathology. These glial cells play pivotal roles in maintaining neuronal homeostasis, including the regulation of metabolism. Emerging evidence suggests a potential association between ASD and inborn errors of metabolism. Therefore, gaining a comprehensive understanding of the functions of microglia and astrocytes in ASD is crucial for the development of effective therapeutic interventions. This review aims to provide a summary of the metabolism of astrocytes and microglia during post-natal development and the evidence of disrupted metabolic pathways in ASD, with particular emphasis on those potentially important for the regulation of neuronal post-natal maturation by astrocytes and microglia.
Keywords
astrocyte, autism spectrum disorders, brain metabolism, fatty acid oxidation, lactate, lipids, microglia, mitochondria
Pubmed
Open Access
Yes
Create date
04/03/2024 17:52
Last modification date
09/08/2024 15:58