Role of amoxicillin serum levels for successful prophylaxis of experimental endocarditis due to tolerant streptococci.

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Ressource 1Download: serval:BIB_4001AD1F5087.P001 (415.93 [Ko])
State: Public
Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_4001AD1F5087
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Role of amoxicillin serum levels for successful prophylaxis of experimental endocarditis due to tolerant streptococci.
Journal
Journal of Infectious Diseases
Author(s)
Fluckiger U., Francioli P., Blaser J., Glauser M.P., Moreillon P.
ISSN
0022-1899 (Print)
ISSN-L
0022-1899
Publication state
Published
Issued date
1994
Volume
169
Number
6
Pages
1397-1400
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The importance of amoxicillin serum profiles for successful prophylaxis of experimental endocarditis in rats was assessed. Animals with catheter-induced vegetations were challenged intravenously with large inocula of Streptococcus sanguis and received one of the following amoxicillin dosages: single or multiple bolus injection of 40 mg/kg; 40 mg/kg administered as a continuous infusion over 12 h; or either 9 or 18 mg/kg administered over 12 or 24 h, respectively. The regimen producing a single transient high peak serum level failed to prevent experimental endocarditis; in contrast, a second injection 6 h after the first resulted in successful prophylaxis. Likewise, the three regimens of continuous, relatively low-dose regimens prevented infections. Thus, the most important parameter for successful prophylaxis was the duration of inhibitory concentration of the drug in the serum. The total dose of antibiotic, the peak serum levels, or the area-under-the-curve values were not predictive of successful prophylaxis.
Keywords
Amoxicillin/administration & dosage, Amoxicillin/blood, Animals, Dose-Response Relationship, Drug, Drug Resistance, Microbial, Endocarditis/microbiology, Endocarditis/prevention & control, Female, Rats, Rats, Wistar, Streptococcal Infections/microbiology, Streptococcal Infections/prevention & control, Streptococcus sanguis/drug effects
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:58
Last modification date
01/10/2019 7:17
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