New insights in the pathogenesis of T-cell lymphomas.

Details

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_3FF9FC10B4B3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
New insights in the pathogenesis of T-cell lymphomas.
Journal
Current opinion in oncology
Author(s)
Lemonnier F., Gaulard P., de Leval L.
ISSN
1531-703X (Electronic)
ISSN-L
1040-8746
Publication state
Published
Issued date
09/2018
Peer-reviewed
Oui
Volume
30
Number
5
Pages
277-284
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Peripheral T-cell lymphomas (PTCLs) represent diverse and aggressive malignancies, with few recent therapeutic improvements. Recent high-throughput genomic studies have revealed the complex mutational landscape of these rare diseases. These novel findings provide the grounds to a more comprehensive classification of these diseases, reflected in the 2017 WHO classification.
Our review is focused on selected PTCL entities. Angioimmunoblastic T-cell lymphoma and other lymphomas derived from T follicular helper cells feature a rather homogeneous mutational landscape. These neoplasms recapitulate a multistep oncogenic process associating epigenetic deregulation, and second hit mutations affecting the T-cell receptor signaling pathway. This model inferred from comprehensive analyses of patients samples, was confirmed in mouse models. Among ALK-negative anaplastic large-cell lymphomas, translocation-associated subsets are found in both systemic and cutaneous types, and the newly described breast implant-associated type is usually indolent. Extranodal lymphomas of the innate immune system also harbor a combination of mutations affecting different classes of epigenetic modifiers, and mutation-induced activation of the Janus Kinase/signal transduction and activator of transcription pathway.
Understanding of PTCL pathogenesis has substantially improved, and oncogenic events have been identified. The current challenge is to mount efficient therapeutic strategies targeting these aberrations to improve patients' outcome.
Keywords
Humans, Lymphoma, T-Cell, Peripheral/diagnosis, Lymphoma, T-Cell, Peripheral/etiology, Lymphoma, T-Cell, Peripheral/genetics, Lymphoma, T-Cell, Peripheral/pathology, Signal Transduction
Pubmed
Web of science
Create date
24/07/2018 12:14
Last modification date
20/08/2019 14:37
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