On-demand, hospital-based, severe acute respiratory coronavirus virus 2 (SARS-CoV-2) genomic epidemiology to support nosocomial outbreak investigations: A prospective molecular epidemiology study.

Details

Serval ID
serval:BIB_3FF82B050096
Type
Article: article from journal or magazin.
Collection
Publications
Title
On-demand, hospital-based, severe acute respiratory coronavirus virus 2 (SARS-CoV-2) genomic epidemiology to support nosocomial outbreak investigations: A prospective molecular epidemiology study.
Journal
Antimicrobial stewardship & healthcare epidemiology
Author(s)
Benoit P., Jolicoeur G., Point F., Soucy C., Normand K., Morency-Potvin P., Gagnon S., Kaufmann D.E., Tremblay C., Coutlée F., Harrigan P.R., Hardy I., Smith M., Savard P., Grandjean Lapierre S.
ISSN
2732-494X (Electronic)
ISSN-L
2732-494X
Publication state
Published
Issued date
2023
Peer-reviewed
Oui
Volume
3
Number
1
Pages
e45
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
We evaluated the added value of infection control-guided, on demand, and locally performed severe acute respiratory coronavirus virus 2 (SARS-CoV-2) genomic sequencing to support outbreak investigation and control in acute-care settings.
This 18-month prospective molecular epidemiology study was conducted at a tertiary-care hospital in Montreal, Canada. When nosocomial transmission was suspected by local infection control, viral genomic sequencing was performed locally for all putative outbreak cases. Molecular and conventional epidemiology data were correlated on a just-in-time basis to improve understanding of coronavirus disease 2019 (COVID-19) transmission and reinforce or adapt control measures.
Between April 2020 and October 2021, 6 outbreaks including 59 nosocomial infections (per the epidemiological definition) were investigated. Genomic data supported 7 distinct transmission clusters involving 6 patients and 26 healthcare workers. We identified multiple distinct modes of transmission, which led to reinforcement and adaptation of infection control measures. Molecular epidemiology data also refuted (n = 14) suspected transmission events in favor of community acquired but institutionally clustered cases.
SARS-CoV-2 genomic sequencing can refute or strengthen transmission hypotheses from conventional nosocomial epidemiological investigations, and guide implementation of setting-specific control strategies. Our study represents a template for prospective, on site, outbreak-focused SARS-CoV-2 sequencing. This approach may become increasingly relevant in a COVID-19 endemic state where systematic sequencing within centralized surveillance programs is not available.
clinicaltrials.gov identifier: NCT05411562.
Pubmed
Web of science
Open Access
Yes
Create date
09/05/2023 12:59
Last modification date
29/11/2024 16:55
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