From In Vitro Data to In Vivo Interspecies Danger Communication: A Study of Chemosensing via the Mouse Grueneberg Ganglion.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_3FD224BF2060
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
From In Vitro Data to In Vivo Interspecies Danger Communication: A Study of Chemosensing via the Mouse Grueneberg Ganglion.
Journal
Animals
Author(s)
Lopes A.C., Brechbühl J., Ferreira F., Amez-Droz M., Broillet M.C.
ISSN
2076-2615 (Print)
ISSN-L
2076-2615
Publication state
Published
Issued date
01/02/2022
Peer-reviewed
Oui
Volume
12
Number
3
Pages
356
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
In the wild, mice have developed survival strategies to detect volatile cues that warn them of potential danger. Specific olfactory neurons found in the Grueneberg ganglion olfactory subsystem can detect alarm pheromones emitted by stressed conspecifics, as well as kairomones involuntarily released by their predators. These volatile chemical cues allow intra- and interspecies communication of danger, respectively. Alarm pheromones, kairomones and bitter taste ligands share a common chemical motif containing sulfur or nitrogen. Interestingly, three specific bitter taste receptors (TAS2Rs) have been found in the Grueneberg ganglion neurons that are implicated in danger signalling pathways. We have recently developed a TAS2R-expressing heterologous system that mimics the Grueneberg ganglion neuron responses after kairomone stimulation. Here, we demonstrated by in vitro, ex vivo and in vivo experiments that the biological secretions from the raccoon (Procyon lotor) and the skunk (Mephitis mephitis) were acting as potent sources of kairomones. They activated the Grueneberg ganglion neurons and induced fear-related behaviours in mice. Identification of new sources of semiochemicals is a first step towards an understanding of the interspecies danger communication that takes place in the Grueneberg ganglion.
Keywords
Grueneberg ganglion, TAS2Rs, chemical communication, danger detection, kairomones, olfaction, predators
Pubmed
Web of science
Open Access
Yes
Create date
19/02/2022 12:11
Last modification date
19/03/2022 7:32
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