Two cases of Takayasu's arteritis occurring under anti-TNF therapy.

Details

Serval ID
serval:BIB_3F716B1CF304
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Two cases of Takayasu's arteritis occurring under anti-TNF therapy.
Journal
Joint, Bone, Spine
Author(s)
Mariani N., So A., Aubry-Rozier B.
ISSN
1778-7254 (Electronic)
ISSN-L
1297-319X
Publication state
Published
Issued date
2013
Volume
80
Number
2
Pages
211-213
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish. PDF type: case report
Abstract
Takayasu's arteritis is a granulomatous, large vessel vasculitis that affects the aorta, its major branches and the pulmonary arteries. Compelling evidence exists to support the notion that Takayasu's arteritis is a T-cell mediated process and that tumor necrosis factor alpha (TNFa) is an important factor in the pathogenesis of this disease. Moreover, encouraging results from recent studies support the use of anti-TNFa therapy for relapsing or resistant cases of Takayasu's arteritis. Here, however, we describe the case of two patients: one with seropositive rheumatoid arthritis, the other with HLA-B27 negative spondylarthropathy, who developed Takayasu's arteritis during treatment with TNFa inhibitors (adalimumab and golimumab respectively). This is the first report of Takayasu's arteritis in rheumatic patients under TNFa blocking agents which suggests the presence of different pathogenetic mechanism in a subgroup of patients with Takayasu's arteritis, as well as a potential role of TNFa blockers as triggers of this disease in some cases.
Pubmed
Web of science
Create date
09/01/2013 14:15
Last modification date
20/08/2019 13:36
Usage data