The binding of immune complexes by the erythrocyte complement receptor 1 (CR1)

Details

Serval ID
serval:BIB_3F6D979EC10A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
The binding of immune complexes by the erythrocyte complement receptor 1 (CR1)
Journal
Immunopharmacology
Author(s)
Pascual  M., Schifferli  J. A.
ISSN
0162-3109
Publication state
Published
Issued date
10/1992
Peer-reviewed
Oui
Volume
24
Number
2
Pages
101-6
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Sep-Oct
Abstract
Immune complexes, which have reacted with complement and bear C3b fragments, bind to the complement receptor 1 (CR1) on human erythrocytes. Indeed, CR1 on erythrocyte serves as a transport system for immune complexes in the circulation so as to prevent immune complex deposition outside the fixed macrophage system. A defect in this transport system has been described in several diseases, in which either complement levels or CR1 number on erythrocytes are diminished. Recent studies have shown that the binding of immune complexes to erythrocytes is favored by the multiple C3b binding sites per receptor and the clustered distribution of CR1 on the erythrocyte surface. Only a few immune complexes bind per erythrocyte but these complexes are tightly bound. The other main function of CR1 on erythrocytes is to enhance the inactivation of C3b by factor I present in plasma. This reaction allows the release of immune complexes from the erythrocyte surface and their transfer to fixed macrophages.
Keywords
Animals Antigen-Antibody Complex/*metabolism Binding Sites Complement C1/immunology/*metabolism Complement C1r/*metabolism Complement C3b/*metabolism Erythrocytes/*immunology Neutrophils/immunology
Pubmed
Web of science
Create date
29/01/2008 13:53
Last modification date
20/08/2019 13:36
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