Dose-dependent inverse relationship between alcohol consumption and serum Lp(a) levels in black African males.

Details

Serval ID
serval:BIB_3F4179937091
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dose-dependent inverse relationship between alcohol consumption and serum Lp(a) levels in black African males.
Journal
Arteriosclerosis, Thrombosis, and Vascular Biology
Author(s)
Fontana P., Mooser V., Bovet P., Shamlaye C., Burnand B., Lenain V., Marcovina S.M., Riesen W., Darioli R.
ISSN
1079-5642
ISSN-L
1079-5642
Publication state
Published
Issued date
04/1999
Peer-reviewed
Oui
Volume
19
Number
4
Pages
1075-1082
Language
english
Abstract
Serum or plasma levels of Lp(a) vary widely between individuals and are higher in Africans and their descendants compared with white persons. In whites, high serum levels of Lp(a) are associated with the premature development of atherosclerosis. In both ethnic groups, serum Lp(a) levels are highly genetically determined and only a few environmental or physiological factors, like testosterone or estrogen, have been shown to lower serum Lp(a) levels. In whites, alcohol consumption is associated with lower serum Lp(a) levels. However, the mechanism underlying this association and whether it holds true for blacks is not known. To address these questions, we analyzed serum Lp(a) levels in 333 middle-aged males of African descent from the Seychelles Islands (Indian Ocean). In addition, we analyzed the size of the apo(a) isoforms and the serum levels of albumin and sex hormones in a subset of 279 subjects. Serum Lp(a) levels were similar in teetotalers (median, 32.5 mg/dL; n=42) and occasional drinkers (median, 34.1 mg/dL; n=112). In contrast, individuals consuming 10 to 80 g of ethanol/d (n=83) and heavy drinkers (>80 g of ethanol/d, n=96) had a 9% and 32% lower median Lp(a) level than teetotalers, respectively (P=0.01). The size distribution of the apo(a) isoforms and the mean serum levels of albumin, estradiol, and luteinizing hormone were similar in teetotalers and occasional drinkers compared with moderate and heavy drinkers. These latter 2 groups had lower serum levels of testosterone and sex hormone-binding globulin. These data indicate that alcohol intake is associated in a dose-dependent manner with lower serum Lp(a) levels in males of African descent and that this association is not related to the size of the apo(a) isoforms, to the synthetic function of the liver, or to sex hormone biochemical status.
Keywords
Adult, Africa, African Continental Ancestry Group, Alcohol Drinking, Cross-Sectional Studies, Dose-Response Relationship, Drug, Humans, Lipoprotein(a), Male, Middle Aged, Multivariate Analysis, Random Allocation, Seychelles
Pubmed
Web of science
Create date
28/01/2008 11:45
Last modification date
20/08/2019 13:36
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