Pleural mesothelioma incidence in Europe: evidence of some deceleration in the increasing trends


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Pleural mesothelioma incidence in Europe: evidence of some deceleration in the increasing trends
Cancer Causes and Control
Montanaro Fabio, Bray Freddie, Gennaro Valerio, Merler Enzo, Tyczynski Jerzy E., Parkin Donald Maxwell, Strnad Marija, Jechov'a Marie, Storm Hans H., Aareleid Tiiu, Hakulinen Timo, Velten Michel, Lef'evre Hacina, Danzon Arlette, Buemi Antoine, Daur'es Jean-Pierre, Menegoz Francois, Raverdy Nicole, Sauvage Martine, Ziegler Hartwig, Comber Harry, Paci Eugenio, Vercelli Marina, De Lisi Vincenzo, Tumino Rosario, Zanetti Roberto, Berrino Franco, Stanta Giorgio, Langmark Froydis, Rachtan Jadwiga, Mezyk Ryszard, Blaszczyk Jerzy, Plesko Ivan, Primic-Zakelj Maja, Martinez Alvaro Canada, Izarzugaza Isabel, Borras Joan, Martinez Garcia Carmen, Garau Isabel, Sanchez Navarro Carmen, Aicua Ardanaz, Barlow Lotti, Torhorst Joachim, Bouchardy Christine, Levi Fabio, Fisch Thomas, Probst Nicole, Visser Otto, Quinn Mike, Gavin Anna, Brewster David, Mikov Marica
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ENCR Working Group
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Réf. IUMSP: R 03/120 SAPHIRID:44945
[Abstract] OBJECTIVE: To summarize the geographical and temporal variations in incidence of pleural mesothelioma in Europe, using the extensive data available from European general cancer registries, and consider these in light of recent trends in asbestos extraction, use and import in European countries. MATERIAL AND METHODS: The data were extracted from the European Cancer Incidence and Mortality database (EUROCIM). The inclusion criteria was acceptance in Volume VII of Cancer Incidence in Five Continents. Truncated age-standardized rates per 100,000 for the ages 40-74 were used to summarise recent geographical variations. Standardized rate ratios and 95% confidence intervals for the periods 1986-1990 and 1991-1995 were compared to assess geographical variations in risk. To investigate changes in the magnitude of most recent trends, regression models fitted to the latest available 10-year period (1988-1997) were compared with trends in the previous decade. Fitted rates in younger (40-64) and older adults (65-74) in the most recent period were also compared. RESULTS: There was a great deal of geographical variation in the risk of mesothelioma, annual rates ranging from around 8 per 100,000 in Scotland, England and The Netherlands, to lower than 1 per 100,000 in Spain (0.96), Estonia (0.85), Poland (0.85) and Yugoslavia, Vojvodina (0.56) among men. The rank of the rates for women was similar to that observed for men, although rates were considerably lower. Between 1978 and 1987, rates in men significantly increased in all countries (excepting Denmark). In the following 10 years, there was a deceleration in trend, and a significant increase was detectable only in England and France. In addition, the magnitude of recent trends in younger men was generally lower than those estimated for older men, in both national and regional cancer registry settings. CONCLUSIONS: While mesothelioma incidence rates are still rising in Europe, a deceleration has started in some countries. A decrease may begin in the next few years in certain European populations considering the deceleration of observed trends in mesothelioma and asbestos exposure, as well as the recent ban on its use. [Authors]
Mesothelioma , Pleural Neoplasms
Web of science
Create date
06/03/2008 15:31
Last modification date
20/08/2019 13:35
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