Metastasis to the rectum: A systematic review of the literature.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_3E92BAF0E09B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Metastasis to the rectum: A systematic review of the literature.
Journal
European journal of surgical oncology
Author(s)
Janjic O., Labgaa I., Hübner M., Demartines N., Joliat G.R.
ISSN
1532-2157 (Electronic)
ISSN-L
0748-7983
Publication state
Published
Issued date
04/2022
Peer-reviewed
Oui
Volume
48
Number
4
Pages
822-833
Language
english
Notes
Publication types: Journal Article ; Review ; Systematic Review
Publication Status: ppublish
Abstract
Metastatic spread to the rectum is a rare finding, and management of rectal metastases (RM) is not standardized. The aim of the present study was to review the evidence on diagnosis, management and outcomes of RM.
A computerized literature search through MEDLINE/PubMed, Embase and the Cochrane databases was performed, applying a combination of terms related to RM. Articles and abstracts were screened and final selection was done after cross-referencing and by use of predefined eligibility criteria.
Final analysis was based on 99 publications totaling 162 patients with RM from 16 different primary tumors. Most common origins of RM were breast (42 patients), stomach (38 patients), and prostate (16 patients). RM occurred metachronously in the majority of patients (77%). The main treatment was surgical resection (n = 32), followed by chemotherapy (n = 16). Median overall survival for breast RM, stomach RM, and prostate RM were 24 months (95% CI 9-39 months), 7 months (95% CI 0-14 months), and 24 months (95% CI 7-41 months), respectively.
RM is a rare and highly heterogeneous condition. Surgical treatment appears to be a valuable treatment option in selected patients, while overall prognosis depends mainly on the primary tumor.
Keywords
Humans, Male, Melanoma, Prognosis, Prostate, Rectum, Skin Neoplasms, Cancer, Malignancy, Secondary tumor
Pubmed
Open Access
Yes
Create date
25/10/2021 9:42
Last modification date
26/04/2022 6:37
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